Evidence map›Paper›PMID 27893933›Full record

Trial reportCancer2017

Cancer and treatment distress psychometric evaluation over time: A BMT CTN 0902 secondary analysis.

Karen L Syrjala, Steven K Sutton, Heather S L Jim, Jennifer M Knight, William A Wood, Stephanie J Lee, Paul B Jacobsen, Muneer H Abidi, Jean C Yi

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2019
    Guideline
  2. Trial
  3. Trial
  4. Trial
  5. Rates and Risk Factors for Post-Traumatic Stress Disorder Symptomatology among Adult Hematopoietic Cell Transplant Recipients and Their Informal Caregivers.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  6. Engagement with INSPIRE, an Online Program for Hematopoietic Cell Transplantation Survivors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  13. Article
  14. Article
  15. Fatigue among post-hematopoietic stem cell transplant patients in Jordan: prevalence and associated factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Karen L SyrjalaClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Steven K SuttonBiostatistics Department, Moffitt Cancer Center, Tampa, Florida.
Heather S L JimHealth Outcomes and Behavior Department, Moffitt Cancer Center, Tampa, Florida.
Jennifer M KnightDepartment of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
William A WoodDivision of Hematology/Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Stephanie J LeeClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Paul B JacobsenHealth Outcomes and Behavior Department, Moffitt Cancer Center, Tampa, Florida.
Muneer H AbidiDivision of Hematology/Oncology, Spectrum Health Cancer Center, Michigan State University, Detroit, Michigan.
Jean C YiBiobehavioral Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · USMoffitt Cancer Center · USMedical College of Wisconsin · USSpectrum Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
Internet Studies to Enhance Long Term Survivorship after Hematologic MalignancyR01CA160684 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SYRJALA, KAREN LESLIE · 2011 to 2015
$3.4M
Translational Research in Blood &Marrow TransplantationU01HL069310 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JONES, RICHARD J · 2001 to 2010
$1.7M
Translational Research in Blood and Marrow TransplantationUG1HL069310 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI RICHARD J JONES · 2017 to 2026
$1.6M
Blood & Marrow Clinical Trials Network - Hutchinson Center Core Clinical SitU10HL069246 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI APPELBAUM, FREDERICK · 2011 to 2016
$1.1M
Sargrastim and Plerixafor vs. Filgrastim for Allogeneic Stem Cell MobilizationU10HL109137 · NHLBI · WASHINGTON UNIVERSITY · PI WESTERVELT, PETER · 2011 to 2016
$937k
Translational Research in Blood and Marrow TranslplantationU10HL069310 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JONES, RICHARD J · 2011 to 2016
$777k
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA160684NCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069310NHLBI NIH HHS U10 HL069246NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U10 HL069310NHLBI NIH HHS U10 HL109137NHLBI NIH HHS UG1 HL069310
6 · The paper itself

Abstract

backgroundRoutine monitoring of cancer-related distress is recognized as essential to quality care and mandated by a major accrediting organization. However, to the authors' knowledge, few cancer-specific measures have been developed to date to assess the multiple cancer-related factors contributing to this distress. In the current study, the authors examined the psychometric properties of the Cancer and Treatment Distress (CTXD) measure over time in hematopoietic cell transplantation (HCT) recipients.

methodsAs a secondary analysis of a multicenter randomized controlled clinical trial, adult patients undergoing autologous or allogeneic HCT completed patient-reported outcomes including the CTXD and the Medical Outcomes Study Short Form-36 (SF-36) before transplantation and 100 days and 180 days after HCT.

resultsAcross 21 transplantation centers, a total of 701 patients consented, underwent transplantation, and were included in the current analyses, 645 of whom were alive at 100 days and 618 of whom were alive at 180 days. Internal consistency reliability was found to be strong for the overall CTXD at the 3 time points: Cronbach alphas (α) were .94, .95, and .95, respectively. Subscale reliability met hypothesized levels of an α>.70 across time, with the lowest reliability noted for the Identity subscale at 180 days (α = .77). Correlations with the SF-36 Mental Health subscale were higher than with the Physical Functioning subscale at each time point, thereby supporting convergent and discriminant validity. Strong correlations of the pretransplantation CTXD with the posttransplantation CTXD and SF-36 Mental Health subscale supported predictive validity.

conclusionsThe CTXD is reliable and valid as a measure of cancer distress both before and after HCT. It may be a useful tool for measuring dimensions of distress and for defining those patients requiring treatment for distress during and after transplantation. Cancer 2017;123:1416-1423. © 2016 American Cancer Society.

Indexed as

PsychometricsStress, PsychologicalAdolescentAdultAgedEmotionsFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedNeoplasmsQuality of LifeSocioeconomic FactorsSurveys and QuestionnairesTransplantation, HomologousCancer and Treatment Distress (CTXD)cancer distress measuredistresshematopoietic cell transplantationpsychometricsreliabilityvalidity

Identifiers

PMID27893933
PMCPMC5384862
OpenAlexW2559360016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.