Evidence map›Paper›PMID 27893763›Full record

ArticlePloS one2016

The Role of Morbid Obesity in the Promotion of Metabolic Disruptions and Non-Alcoholic Steatohepatitis by Helicobacter Pylori.

Albert Lecube, Silvia Valladares, Carolina López-Cano, Liliana Gutiérrez, Andreea Ciudin, José Manuel Fort, Josep Maria Reñé, Xavier Matias-Guiu, Inés de Torres, Marta Bueno and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Relationship ofCanadian journal of gastroenterology & hepatology · 2023
    Pooled it
  2. Helicobacter pylori Infection and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Pooled it
  3. Pooled it
  4. Persistently ActiveJournal of clinical medicine · 2025
    Article
  5. Article
  6. Review
  7. Observational
  8. Involvement ofInternational journal of environmental research and public health · 2022
    Article
  9. No evidence for a causal link betweenFrontiers in microbiology · 2022
    Article
  10. ActiveJournal of clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Albert LecubeEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.ORCID http://orcid.org/0000-0001-9684-0183
Silvia ValladaresEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
Carolina López-CanoEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Liliana GutiérrezEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Andreea CiudinEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
José Manuel FortEndocrine, Bariatric and Metabolic Surgery Unit, IFSO Centre of Excellence, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
Josep Maria ReñéGastroenterology Department. Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Xavier Matias-GuiuDepartment of Pathology and Molecular Genetics, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Inés de TorresPathology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
Marta BuenoEndocrinology and Nutrition Department, EASO Collaborating Centre for Obesity Management, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Judit PallarésDepartment of Pathology and Molecular Genetics, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Juan Antonio BaenaGastrointestinal Surgery Department. Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica (IRB) and University of Lleida, Lleida, Spain.
Universitat de Lleida · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant and no studies exist in morbidly obese patients, in which both insulin resistance and inflammation coexist. MATERIAL AND

methodsCross-sectional study to evaluate the relationship between HP infection and alterations in carbohydrate metabolism, lipid profile, inflammation markers, and liver disease in patients awaiting for bariatric surgery. HP infection was histologically assessed in gastric antrum biopsy from 416 subjects. Liver biopsy was also available in 93 subjects.

resultsBoth impaired fasting glucose and T2D were similar when comparing subjects with and without HP infection (24.2% vs. 22%, p = 0.290 and 29.4% vs. 29.1%, p = 0.916, respectively), with no differences between groups in the HOMA-IR, lipid profile neither inflammatory parameters. However, HP infection was higher among subjects with a BMI ≥ 40.0 kg/m2 in comparison with lower degrees of obesity (71.7% vs. 60.0%, p = 0.041). In addition, subjects without HP infection showed higher degrees of steatosis (44.1±26.4% vs. 32.0±20.7%, p = 0.038), as well as a lower prevalence of non-alcoholic steatohepatitis (9.3% vs. 30.7%, p = 0.023).

conclusionsIn patients with morbid obesity, HP infection does not seem to be associated with abnormal carbohydrate metabolism. In addition, less advanced degrees of non-alcoholic fatty disease were observed. We suggest that low-grade inflammation that accompanies obesity mitigates the diabetogenic effect of HP, so the presence of obesity should be considered in studies that evaluate the HP metabolic effects.

Indexed as

AdultBlood GlucoseCarbohydrate MetabolismCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesity, MorbidBlood Glucose

Identifiers

PMID27893763
PMCPMC5125598
OpenAlexW2558820982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.