ArticlePloS one2016
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity.The Journal of clinical investigation · 2021Trial
- EBV reactivation and immunoparalysis indicate a harmful immune endotype in sepsis.Critical care (London, England) · 2026Article
- Frontiers and literature review on non-aspiration stroke-associated infections.European journal of medical research · 2026Review
- Human Leukocyte Antigen-DR Expression on Monocytes Is a Useful Predictor in a Systemic Inflammation Response-Based Prognostic Model in Advanced Non-Small Cell Lung Cancer.International journal of molecular sciences · 2025Article
- Identifying Key Hematological and Biochemical Indicators of Disease Severity in COVID-19 and Non-COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Challenges of monocyte HLA-DR targeted immunomodulation in sepsis-a prospective observational cohort study.Frontiers in immunology · 2025Observational
- The role of trained immunity in sepsis.Frontiers in immunology · 2024Review
- Article
- The Dynamics of Circulating Heparin-Binding Protein: Implications for Its Use as a Biomarker.Journal of innate immunity · 2022Article
- Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.Science translational medicine · 2021Article
- Comprehensive mapping of immune perturbations associated with severe COVID-19.Science immunology · 2020Article
- Immunity check should be performed for all patients with septic shock? No.Intensive care medicine · 2020Article
- Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.JCI insight · 2019Article
- Advances in the understanding and treatment of sepsis-induced immunosuppression.Nature reviews. Nephrology · 2018Review
- Precision Immunotherapy for Sepsis.Frontiers in immunology · 2018Review
- Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses-an animal study.Clinical epigenetics · 2018Article
- Reduced NLRP3 Gene Expression Limits the IL-1Mediators of inflammation · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe downregulation of blood monocyte HLA-DR expression also occurs in tissue infiltrative cells in a context of acute clinical inflammation, especially sepsis. This context favors the development of secondary infections and results from various mechanisms. Little is known about HLA-DR expression on bone marrow (BM) cells of the monocyte lineage, the source of circulating monocytes. This study analyzed the BM HLA-DR expression in ICU patients compared to BM monocytes from non-ICU patients and to blood monocytes of control healthy donors. A potential dysfunction of myeloid differentiation was investigated in a sub-population of these ICU patients to characterize the phenotype of the immature forms of monocytes and granulocytes in BM. METHODS AND
findingsBM and blood were drawn from 33 ICU and 9 non-ICU patients having a BM analysis to precise the etiology of abnormal low count in blood cells. The data were compared with blood cells of 28 control donors. Flow cytometry was used for both HLA-DR expression and phenotyping of immature forms of monocytes and granulocytes. HLA-DR expression was downregulated in both blood and BM monocyte in ICU patients compared to BM of non-ICU patients and blood of control donors. Amplitude of HLA-DR downregulation was comparable in septic and non-septic ICU patients. The phenotype of immature forms of monocytes and granulocytes in BM (n = 11) did not show abnormal myeloid (monocyte + granulocyte) differentiation.
conclusionThe downregulation of HLA-DR in BM monocyte lineage is present in ICU patients without major changes in myeloid cells. It may result from a regulation mediated by soluble and/or neuro-endocrine factors present in BM cell microenvironment.
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