ArticleNature nanotechnology2017
Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors.
Article in Nature nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 137 citations in OpenAlex.
- Functionalized Fluorescent Nanodiamonds Reveal Therapeutic Protein Clearance Through ENDOTAC Linked to AUTOTAC.Advanced healthcare materials · 2026Article
- 3D positioning and optically detected magnetic resonance of intracellular fluorescent nanodiamonds using a multi-plane microscope.Biophysics reports · 2026Article
- Molecular engineering of individual dye-based nanoparticle photostability for ultrabright two-photon fluorescence.Beilstein journal of nanotechnology · 2026Article
- Visualising sub-second dynamics of nanoparticle extravasationbioRxiv : the preprint server for biology · 2025Article
- Bright Quantum-Grade Fluorescent Nanodiamonds.ACS nano · 2024Article
- Neuronal maturation-dependent nano-neuro interaction and modulation.Nanoscale horizons · 2023Article
- Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues.Analytical chemistry · 2023Article
- Diamond quantum sensors in microfluidics technology.Biomicrofluidics · 2023Article
- Fluorescent nanodiamond labels: Size and concentration matters for sperm cell viability.Materials today. Bio · 2023Article
- Green Synthesis of Carbon Nanoparticles (CNPs) from Biomass for Biomedical Applications.International journal of molecular sciences · 2023Review
- Intracellular Relaxometry, Challenges, and Future Directions.ACS central science · 2022Review
- On-Demand, Direct Printing of Nanodiamonds at the Quantum Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Review
- Recent technological advances in correlative light and electron microscopy for the comprehensive analysis of neural circuits.Frontiers in neuroanatomy · 2022Review
- Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal-Free Luminophores for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Time for NanoNeuro.Nature methods · 2021Review
- Quantifying nanodiamonds biodistribution in whole cells with correlative iono-nanoscopy.Nature communications · 2021Article
- Dual-process brain mitochondria isolation preserves function and clarifies protein composition.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry.Scientific reports · 2021Article
- Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for HFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain diseases such as autism and Alzheimer's disease (each inflicting >1% of the world population) involve a large network of genes displaying subtle changes in their expression. Abnormalities in intraneuronal transport have been linked to genetic risk factors found in patients, suggesting the relevance of measuring this key biological process. However, current techniques are not sensitive enough to detect minor abnormalities. Here we report a sensitive method to measure the changes in intraneuronal transport induced by brain-disease-related genetic risk factors using fluorescent nanodiamonds (FNDs). We show that the high brightness, photostability and absence of cytotoxicity allow FNDs to be tracked inside the branches of dissociated neurons with a spatial resolution of 12 nm and a temporal resolution of 50 ms. As proof of principle, we applied the FND tracking assay on two transgenic mouse lines that mimic the slight changes in protein concentration (∼30%) found in the brains of patients. In both cases, we show that the FND assay is sufficiently sensitive to detect these changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.