ArticlePain2017
Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles.
Article in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 7 of them syntheses that pooled it.
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The trial behind it
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Who cites it
254 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- [The EAN-NeuPSIG guideline on the diagnosis of neuropathic pain-a summary].Schmerz (Berlin, Germany) · 2026Guideline
- Photobiomodulation in chronic pain: a systematic review of randomized clinical trials.Frontiers in integrative neuroscience · 2026Pooled it
- Pooled it
- Pooled it
- A protocol for the systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain.BMJ open science · 2021Pooled it
- Altered pain processing in patients with type 1 and 2 diabetes: systematic review and meta-analysis of pain detection thresholds and pain modulation mechanisms.BMJ open diabetes research & care · 2020Pooled it
- Pregabalin for neuropathic pain in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Clinical Efficacy of Neurorrhaphy in Anterolateral Thigh Flap Reconstruction for Tongue Cancer Defects: A Randomized Controlled Trial.Annals of surgical oncology · 2026Trial
- Botulinum Toxin A in the treatment of frostbite sequelae - results from a blinded, early-phase, comparative trial.International journal of circumpolar health · 2023Trial
- Mechanistic and thermal characterization of acupuncture for chemotherapy-induced peripheral neuropathy as measured by quantitative sensory testing.Breast cancer research and treatment · 2023Trial
- Predicting Treatment Response with Sensory Phenotyping in Post-Traumatic Neuropathic Pain.Pain medicine (Malden, Mass.) · 2022Trial
- Trial
- Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial.Journal of translational medicine · 2021Trial
- Differential response to scrambler therapy by neuropathic pain phenotypes.Scientific reports · 2021Trial
- Stratified versus usual care for the management of primary care patients with sciatica: the SCOPiC RCT.Health technology assessment (Winchester, England) · 2020Trial
- Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.European journal of anaesthesiology · 2019Trial
- Psychometric validation of the Turkish version of the Neuropathic Pain Symptom Inventory.Turkish journal of physical medicine and rehabilitation · 2026Article
- Longitudinal Changes in Somatosensory Function and Their Association with Pain Trajectory Groups in a Portuguese Cancer Center Cohort.Biomedicines · 2026Article
- Perineuromal hydrodissection for acute postamputation pain? An observational study in a time of war.Regional anesthesia and pain medicine · 2026Observational
- Postherpetic Neuralgia: Mechanisms, Risk Factors, and Stratified Management-A Narrative Review.CNS neuroscience & therapeutics · 2026Review
194 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with neuropathic pain are heterogeneous in etiology, pathophysiology, and clinical appearance. They exhibit a variety of pain-related sensory symptoms and signs (sensory profile). Different sensory profiles might indicate different classes of neurobiological mechanisms, and hence subgroups with different sensory profiles might respond differently to treatment. The aim of the investigation was to identify subgroups in a large sample of patients with neuropathic pain using hypothesis-free statistical methods on the database of 3 large multinational research networks (German Research Network on Neuropathic Pain (DFNS), IMI-Europain, and Neuropain). Standardized quantitative sensory testing was used in 902 (test cohort) and 233 (validation cohort) patients with peripheral neuropathic pain of different etiologies. For subgrouping, we performed a cluster analysis using 13 quantitative sensory testing parameters. Three distinct subgroups with characteristic sensory profiles were identified and replicated. Cluster 1 (sensory loss, 42%) showed a loss of small and large fiber function in combination with paradoxical heat sensations. Cluster 2 (thermal hyperalgesia, 33%) was characterized by preserved sensory functions in combination with heat and cold hyperalgesia and mild dynamic mechanical allodynia. Cluster 3 (mechanical hyperalgesia, 24%) was characterized by a loss of small fiber function in combination with pinprick hyperalgesia and dynamic mechanical allodynia. All clusters occurred across etiologies but frequencies differed. We present a new approach of subgrouping patients with peripheral neuropathic pain of different etiologies according to intrinsic sensory profiles. These 3 profiles may be related to pathophysiological mechanisms and may be useful in clinical trial design to enrich the study population for treatment responders.
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