Evidence map›Paper›PMID 27893402›Full record

ArticleIEEE journal of biomedical and health informatics2017

A Convolutional Neural Network for Automatic Characterization of Plaque Composition in Carotid Ultrasound.

Karim Lekadir, Alfiia Galimzianova, Angels Betriu, Maria Del Mar Vila, Laura Igual, Daniel L Rubin, Elvira Fernandez, Petia Radeva, Sandy Napel

Registry-linked trialAbstract read
In one paragraph

Article in IEEE journal of biomedical and health informatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05836246 (The Development of Artificial Intelligence), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05836246 unknown statusnot on this mapstarted 2020, after this paper: background citation

The Development of Artificial Intelligence (AI) Based High Performance Structural-functional and Quantitative Ultrasound Imaging Software Platform

Typeobservational_patient_registrySponsorSeoul National University Bundang HospitalRan2020 to 2026Enrolled196ConditionsChronic Liver Disease, Thyroid Disease, Benign Breast Disease, Malignant Breast Neoplasm
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Artificial intelligence in diagnostic ultrasonography.Diagnostic and interventional radiology (Ankara, Turkey) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Karim Lekadir
Alfiia Galimzianova
Angels Betriu
Maria Del Mar Vila
Laura Igual
Daniel L Rubin
Elvira Fernandez
Petia Radeva
Sandy Napel

Funding

Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung CancerR01CA160251 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., PLEVRITIS, SYLVIA KATINA · 2011 to 2015
$2.9M
Computing, Optimizing, and Evaluating Quantitative Cancer Imaging BiomarkersU01CA187947 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., RUBIN, DANIEL L · 2015 to 2019
$2.9M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
NCI NIH HHS R01 CA160251NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA187947NCI NIH HHS U01 CA190214
6 · The paper itself

Abstract

Characterization of carotid plaque composition, more specifically the amount of lipid core, fibrous tissue, and calcified tissue, is an important task for the identification of plaques that are prone to rupture, and thus for early risk estimation of cardiovascular and cerebrovascular events. Due to its low costs and wide availability, carotid ultrasound has the potential to become the modality of choice for plaque characterization in clinical practice. However, its significant image noise, coupled with the small size of the plaques and their complex appearance, makes it difficult for automated techniques to discriminate between the different plaque constituents. In this paper, we propose to address this challenging problem by exploiting the unique capabilities of the emerging deep learning framework. More specifically, and unlike existing works which require a priori definition of specific imaging features or thresholding values, we propose to build a convolutional neural network (CNN) that will automatically extract from the images the information that is optimal for the identification of the different plaque constituents. We used approximately 90 000 patches extracted from a database of images and corresponding expert plaque characterizations to train and to validate the proposed CNN. The results of cross-validation experiments show a correlation of about 0.90 with the clinical assessment for the estimation of lipid core, fibrous cap, and calcified tissue areas, indicating the potential of deep learning for the challenging task of automatic characterization of plaque composition in carotid ultrasound.

Indexed as

Neural Networks, ComputerCarotid ArteriesCarotid Artery DiseasesHumansImage Processing, Computer-AssistedPlaque, AtheroscleroticUltrasonography

Identifiers

PMID27893402
PMCPMC5293622

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.