ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2017
Enhanced Control of Cortical Pyramidal Neurons With Micromagnetic Stimulation.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation.Journal of neural engineering · 2025Article
- Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Functional and Effective Connectivity Underlying Semantic Verbal Fluency.Brain topography · 2024Article
- Transparent and Conformal Microcoil Arrays for Spatially Selective Neuronal Activation.Device · 2024Article
- Cellular mechanisms underlying carry-over effects after magnetic stimulation.Scientific reports · 2024Article
- System-level biological effects of extremely low-frequency electromagnetic fields: anFrontiers in neuroscience · 2023Review
- Improving focality and consistency in micromagnetic stimulation.Frontiers in computational neuroscience · 2023Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Thermal effects on neurons during stimulation of the brain.Journal of neural engineering · 2022Article
- Micro-magnetic stimulation of primary visual cortex induces focal and sustained activation of secondary visual cortex.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation.Scientific reports · 2022Article
- Article
- Finding the Location of Axonal Activation by a Miniature Magnetic Coil.Frontiers in computational neuroscience · 2022Article
- Short-pulsed micro-magnetic stimulation of the vagus nerve.Frontiers in physiology · 2022Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Selective Activation of Cortical Columns Using Multichannel Magnetic Stimulation With a Bent Flat Microwire Array.IEEE transactions on bio-medical engineering · 2021Article
- Somatic inhibition by microscopic magnetic stimulation.Scientific reports · 2021Article
- Effect of Pulse Duration and Direction on Plasticity Induced by 5 Hz Repetitive Transcranial Magnetic Stimulation in Correlation With Neuronal Depolarization.Frontiers in neuroscience · 2021Article
- Inducing lateralized phosphenes over the occipital lobe using transcranial magnetic stimulation to navigate a virtual environment.PloS one · 2021Article
- MEMS inductor fabrication and emerging applications in power electronics and neurotechnologies.Microsystems & nanoengineering · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Magnetic stimulation is less sensitive to the inflammatory reactions that plague conventional electrode-based cortical implants and therefore may be useful as a next-generation (implanted) cortical prosthetic. The fields arising from micro-coils are quite small however and thus, their ability to modulate cortical activity must first be established. Here, we show that layer V pyramidal neurons (PNs) can be strongly activated by micro-coil stimulation and further, the asymmetric fields arising from such coils do not simultaneously activate horizontally-oriented axon fibers, thus confining activation to a focal region around the coil. The spatially-narrow fields from micro-coils allowed the sensitivity of different regions within a single PN to be compared: while the proximal axon was most sensitive in naïve cells, repetitive stimulation over the apical dendrite led to a change in state of the neuron that reduced thresholds there to below those of the axon. Thus, our results raise the possibility that regardless of the mode of stimulation, penetration depths that target specific portions of the apical dendrite may actually be more effective than those that target Layer 6. Interestingly, the state change had similar properties to state changes described previously at the systems level, suggesting a possible neuronal mechanism underlying such responses.
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Registered trials
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