Evidence map›Paper›PMID 27893186›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2017

The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue.

Adrien Lücker, Timothy W Secomb, Bruno Weber, Patrick Jenny

Open access · bronzeAbstract read
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 57 citations in OpenAlex.

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  8. Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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  9. Frequency selective neuronal modulation triggers spreading depolarizations in the rat endothelin-1 model of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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  15. Observational
  16. Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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  17. The mass transfer coefficient for oxygen transport from blood to tissue in cerebral cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Adrien LückerInstitute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.
Timothy W SecombDepartment of Physiology, University of Arizona, Tucson, AZ, USA.
Bruno WeberInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Patrick JennyInstitute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.
ETH Zurich · CHUniversity of Arizona · USUniversity of Zurich · CH

Funding

MICROVASCULAR BLOOD RHEOLOGY &RED BLOOD CELL MECHANICSR01HL034555 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 1988 to 2020
$3.2M
Flow regulation and Oxygen transpot in microcirculationR01HL070657 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2002 to 2014
$2.0M
NHLBI NIH HHS R01 HL034555NHLBI NIH HHS R01 HL070657
6 · The paper itself

Abstract

objectiveOxygen transport to parenchymal cells occurs mainly at the microvascular level and depends on convective RBC flux, which is proportional in an individual capillary to the product of capillary hematocrit and RBC velocity. This study investigates the relative influence of these two factors on tissue PO

methodsA simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity, and RBC flow on tissue oxygenation around capillaries. Predicted tissue PO

resultsHematocrit is shown to have a larger influence on tissue PO

conclusionsFor a given RBC flux in a capillary, the PO

Indexed as

Blood Flow VelocityHematocritAnimalsBiological TransportCapillariesErythrocytesHumansModels, BiologicalOxygenOxygen ConsumptionOxygenblood flowmathematical modelingtissue oxygenation

Identifiers

PMID27893186
PMCPMC5404950
OpenAlexW2559605063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.