Evidence map›Paper›PMID 27893087›Full record

Trial reportAnnals of internal medicine2017

Targeting Functional Decline in Alzheimer Disease: A Randomized Trial.

Christopher M Callahan, Malaz A Boustani, Arlene A Schmid, Michael A LaMantia, Mary G Austrom, Douglas K Miller, Sujuan Gao, Denisha Y Ferguson, Kathleen A Lane, Hugh C Hendrie

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01314950 (Alzheimer's Disease Multiple Intervention Trial), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01314950 nacompletednot on this map

Alzheimer's Disease Multiple Intervention Trial

TypeinterventionalSponsorIndiana UniversityRan2010 to 2015Enrolled180ConditionsAlzheimer's DiseaseArmsHome based occupational therapy, Best practices primary care
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Cognitive rehabilitation for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2023
    Pooled it
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  6. Pooled it
  7. Trial
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  9. Review
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  11. Review
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  16. Article
  17. Racial and Ethnic Disparities in Serious Psychological Distress Among Those With Alzheimer's Disease and Related Dementias.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Christopher M CallahanFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Malaz A BoustaniFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Arlene A SchmidFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Michael A LaMantiaFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Mary G AustromFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Douglas K MillerFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Sujuan GaoFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Denisha Y FergusonFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Kathleen A LaneFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Hugh C HendrieFrom Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
Regenstrief Institute · US

Funding

Alzheimer's Disease Multiple Intervention Trial - ADMITR01AG034946 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI CALLAHAN, CHRISTOPHER M · 2010 to 2014
$2.6M
NIA NIH HHS R01 AG034946
6 · The paper itself

Abstract

backgroundAlzheimer disease results in progressive functional decline, leading to loss of independence.

objectiveTo determine whether collaborative care plus 2 years of home-based occupational therapy delays functional decline.

designRandomized, controlled clinical trial. (ClinicalTrials.gov: NCT01314950).

settingUrban public health system. PATIENTS: 180 community-dwelling participants with Alzheimer disease and their informal caregivers.

interventionAll participants received collaborative care for dementia. Patients in the intervention group also received in-home occupational therapy delivered in 24 sessions over 2 years. MEASUREMENTS: The primary outcome measure was the Alzheimer's Disease Cooperative Study Group Activities of Daily Living Scale (ADCS ADL); performance-based measures included the Short Physical Performance Battery (SPPB) and Short Portable Sarcopenia Measure (SPSM).

resultsAt baseline, clinical characteristics did not differ significantly between groups; the mean Mini-Mental State Examination score for both groups was 19 (SD, 7). The intervention group received a median of 18 home visits from the study occupational therapists. In both groups, ADCS ADL scores declined over 24 months. At the primary end point of 24 months, ADCS ADL scores did not differ between groups (mean difference, 2.34 [95% CI, -5.27 to 9.96]). We also could not definitively demonstrate between-group differences in mean SPPB or SPSM values. LIMITATION: The results of this trial are indeterminate and do not rule out potential clinically important effects of the intervention.

conclusionThe authors could not definitively demonstrate whether the addition of 2 years of in-home occupational therapy to a collaborative care management model slowed the rate of functional decline among persons with Alzheimer disease. This trial underscores the burden undertaken by caregivers as they provide care for family members with Alzheimer disease and the difficulty in slowing functional decline. PRIMARY FUNDING SOURCE: National Institute on Aging.

Indexed as

Home Care ServicesOccupational TherapyActivities of Daily LivingAgedAlzheimer DiseaseCaregiversFemaleHumansMaleSingle-Blind MethodTreatment Outcome

Identifiers

PMID27893087
PMCPMC5554402
OpenAlexW2557501717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.