ArticleJournal of biomechanical engineering2017
Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model.
Article in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Computational modeling of tissue damage preceding aortic dissection: a coupled biphasic and reactive viscoelastic framework.Biomechanics and modeling in mechanobiology · 2026Article
- Biomechanical Variation of the Vessel Wall Along the Length of the Healthy Aorta-Linking Geometric, Flow-, and Pressure-Mediated Adaptations.Journal of biomechanical engineering · 2026Review
- Comprehensive characterization of nonlinear viscoelastic properties of arterial tissues using guided-wave optical coherence elastography.Communications physics · 2026Article
- Dissection Propagation via Avalanches in Human Descending Thoracic Aorta: Effect of Aging.Acta biomaterialia · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Effects of age, elastin density, and glycosaminoglycan accumulation on the delamination strength of human thoracic and abdominal aortas.Acta biomaterialia · 2024Article
- Atherosclerotic Calcifications Have a Local Effect on the Peel Behavior of Human Aortic Media.Journal of biomechanical engineering · 2024Article
- Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes.American journal of physiology. Heart and circulatory physiology · 2024Article
- A two-scale numerical study on the mechanobiology of abdominal aortic aneurysms.Journal of the Royal Society, Interface · 2023Article
- The non-affine fiber network solver: A multiscale fiber network material model for finite-element analysis.Journal of the mechanical behavior of biomedical materials · 2023Article
- A discrete fiber network finite element model of arterial elastin network considering inter-fiber crosslinking property and density.Journal of the mechanical behavior of biomedical materials · 2022Article
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- From Uniaxial Testing of Isolated Layers to a Tri-Layered Arterial Wall: A Novel Constitutive Modelling Framework.Annals of biomedical engineering · 2021Article
- A Hybrid Microstructural-Continuum Multiscale Approach for Modeling Hyperelastic Fibrous Soft Tissue.Journal Of Elasticity · 2021Article
- Bio-chemo-mechanics of the thoracic aorta.Vascular biology (Bristol, England) · 2021Review
- Investigation of Pathophysiological Aspects of Aortic Growth, Remodeling, and Failure Using a Discrete-Fiber Microstructural Model.Journal of biomechanical engineering · 2020Article
- The functional limits of the aneurysmal aortic root. A unique pressure testing apparatus.Journal of cardiothoracic surgery · 2020Article
- Biomechanics of infarcted left ventricle: a review of modelling.Biomedical engineering letters · 2020Review
- Recent Advances in Biomechanical Characterization of Thoracic Aortic Aneurysms.Frontiers in cardiovascular medicine · 2020Review
- Ex Vivo Mechanical Tests and Multiscale Computational Modeling Highlight the Importance of Intramural Shear Stress in Ascending Thoracic Aortic Aneurysms.Journal of biomechanical engineering · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ascending thoracic aorta is poorly understood mechanically, especially its risk of dissection. To make better predictions of dissection risk, more information about the multidimensional failure behavior of the tissue is needed, and this information must be incorporated into an appropriate theoretical/computational model. Toward the creation of such a model, uniaxial, equibiaxial, peel, and shear lap tests were performed on healthy porcine ascending aorta samples. Uniaxial and equibiaxial tests showed anisotropy with greater stiffness and strength in the circumferential direction. Shear lap tests showed catastrophic failure at shear stresses (150-200 kPa) much lower than uniaxial tests (750-2500 kPa), consistent with the low peel tension (∼60 mN/mm). A novel multiscale computational model, including both prefailure and failure mechanics of the aorta, was developed. The microstructural part of the model included contributions from a collagen-reinforced elastin sheet and interlamellar connections representing fibrillin and smooth muscle. Components were represented as nonlinear fibers that failed at a critical stretch. Multiscale simulations of the different experiments were performed, and the model, appropriately specified, agreed well with all experimental data, representing a uniquely complete structure-based description of aorta mechanics. In addition, our experiments and model demonstrate the very low strength of the aorta in radial shear, suggesting an important possible mechanism for aortic dissection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.