ArticleScientific reports2016
Effect of sex, age and genetics on crossover interference in cattle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Sex differences in crossover interference in house mice.G3 (Bethesda, Md.) · 2026Article
- Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle.Scientific reports · 2025Article
- Sex differences in crossover interference in house mice.bioRxiv : the preprint server for biology · 2025Article
- Independent genetic basis of meiotic crossover positioning and interference in domestic pigs.Scientific reports · 2025Article
- Article
- Genetic background affects the strength of crossover interference in house mice.bioRxiv : the preprint server for biology · 2024Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
- Genomic regions and biological mechanisms underlying climatic resilience traits derived from automatically-recorded vaginal temperature in lactating sows under heat stress conditions.Frontiers in genetics · 2024Article
- Genome-wide association and functional genomic analyses for body conformation traits in North American Holstein cattle.Frontiers in genetics · 2024Article
- Cytological Analysis of Crossover Frequency and Distribution in Male Meiosis of Cardueline Finches (Fringillidae, Aves).Animals : an open access journal from MDPI · 2023Article
- A Novel Strategy to Reveal the Landscape of Crossovers in an F1 Hybrid Population ofPlants (Basel, Switzerland) · 2022Article
- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- Accuracy of Genomic Selection for Important Economic Traits of Cashmere and Meat Goats Assessed by Simulation Study.Frontiers in veterinary science · 2022Article
- Article
- Effect of Temperature and Maternal Age on Recombination Rate in Cattle.Frontiers in genetics · 2021Article
- Genetic architecture of individual variation in recombination rate on the X chromosome in cattle.Heredity · 2020Article
- Sex Differences in the Recombination Landscape.The American naturalist · 2020Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
- Substantial Heritable Variation in Recombination Rate on Multiple Scales in Honeybees and Bumblebees.Genetics · 2019Article
- A first genetic portrait of synaptonemal complex variation.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crossovers generated by homologous recombination ensure proper chromosome segregation during meiosis. Crossover interference results in chiasmata being more evenly distributed along chromosomes, but the mechanism underlying crossover interference remains elusive. Based on large pedigrees of Holstein and Jersey cattle with genotype data, we extracted three-generation families, including 147,327 male and 71,687 female meioses in Holstein, and 108,163 male and 37,008 female meioses in Jersey, respectively. We identified crossovers in these meioses and fitted the Housworth-Stahl "interference-escape" model to study crossover interference patterns in the cattle genome. Our result reveals that the degree of crossover interference is stronger in females than in males. We found evidence for inter-chromosomal variation in the level of crossover interference, with smaller chromosomes exhibiting stronger interference. In addition, crossover interference levels decreased with maternal age. Finally, sex-specific GWAS analyses identified one locus near the NEK9 gene on chromosome 10 to have a significant effect on crossover interference levels. This locus has been previously associated with recombination rate in cattle. Collectively, this large-scale analysis provided a comprehensive description of crossover interference across chromosome, sex and age groups, identified associated candidate genes, and produced useful insights into the mechanism of crossover interference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.