ArticleScientific reports2016
In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Pigmentation-dependent expression of pheomelanogenesis-related genes in human melanoma cells.Postepy dermatologii i alergologii · 2026Article
- Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma.Biosensors · 2025Review
- Article
- In vivo imaging with a fast large-area multiphoton exoscope (FLAME) captures the melanin distribution heterogeneity in human skin.Scientific reports · 2022Article
- In vivo melanin 3D quantification and z-epidermal distribution by multiphoton FLIM, phasor and Pseudo-FLIM analyses.Scientific reports · 2022Article
- Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques.Scientific reports · 2019Article
- Pheomelanin synthesis varies with protein food abundance in developing goshawks.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging.Biomedical optics express · 2018Article
- Solar and terrestrial radiations explain continental-scale variation in bird pigmentation.Oecologia · 2018Article
- Following laser induced changes of plant phenylpropanoids by Raman microscopy.Scientific reports · 2018Article
- Six-wave mixing coherent anti-Stokes Raman scattering microscopy.Biomedical optics express · 2018Article
- Label-free imaging of hemoglobin degradation and hemosiderin formation in brain tissues with femtosecond pump-probe microscopy.Theranostics · 2018Article
- Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis.Oecologia · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Melanoma is the most deadly form of skin cancer with a yearly global incidence over 232,000 patients. Individuals with fair skin and red hair exhibit the highest risk for developing melanoma, with evidence suggesting the red/blond pigment known as pheomelanin may elevate melanoma risk through both UV radiation-dependent and -independent mechanisms. Although the ability to identify, characterize, and monitor pheomelanin within skin is vital for improving our understanding of the underlying biology of these lesions, no tools exist for real-time, in vivo detection of the pigment. Here we show that the distribution of pheomelanin in cells and tissues can be visually characterized non-destructively and noninvasively in vivo with coherent anti-Stokes Raman scattering (CARS) microscopy, a label-free vibrational imaging technique. We validated our CARS imaging strategy in vitro to in vivo with synthetic pheomelanin, isolated melanocytes, and the Mc1r
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