ArticleScientific reports2016
Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 119 citations in OpenAlex.
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- Genistein supplementation modulates the intestinal microbiota-liver-lumbar muscle metabolic axis in DLY commercial pigs without concomitant changes in growth performance.Frontiers in microbiology · 2025Article
- Identification and Profiling of Primary Metabolites Through GC-MS and Associated Data Processing.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Efficient screening and discovery of umami peptides in Douchi enhanced by molecular dynamics simulations.Food chemistry: X · 2024Article
- Leaf rust (Puccinia recondita f. sp. secalis) triggers substantial changes in rye (Secale cereale L.) at the transcriptome and metabolome levels.BMC plant biology · 2024Article
- Transcriptome analysis in Aegilops tauschii unravels further insights into genetic control of stripe rust resistance.Planta · 2024Article
- Transcriptome differential expression analysis of defoliation in different lemon varieties under drought treatment.PloS one · 2024Article
- Physiological and Proteomic Changes inGenes · 2023Article
- Identification of novel α-glucosidase and ACE inhibitory peptides from Douchi using peptidomics approach and molecular docking.Food chemistry: X · 2023Article
- Plant Host Traits Mediated by Foliar Fungal Symbionts and Secondary Metabolites.Microbial ecology · 2023Article
- New insights into the occurrence of continuous cropping obstacles in pea (Pisum sativum L.) from soil bacterial communities, root metabolism and gene transcription.BMC plant biology · 2023Article
- Oral microbial interactions from an ecological perspective: a narrative review.Frontiers in oral health · 2023Review
- Comparative secretomic and proteomic analysis reveal multiple defensive strategies developed byFrontiers in microbiology · 2023Article
- Anthocyanins fromFrontiers in microbiology · 2023Article
- Genes Associated with Biological Nitrogen Fixation Efficiency Identified Using RNA Sequencing in Red Clover (Life (Basel, Switzerland) · 2022Article
- Reference Genes Selection ofJournal of fungi (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion in terms of microbe-induced metabolic responses. Through metabolic pathway enrichment and mapping, we found that the host altered its metabolite levels, resulting in accumulation of tetrose and pentose sugar alcohols, in response to this fungus. We then used a multiple linear regression model to evaluate the effect of the interaction between this abnormal accumulation of sugar alcohol and the group variable (control/parasitism). The results revealed that this accumulation resulted in deficiency in the supply of specific sugars, which led to a lack of amino sugar and nucleotide sugar metabolism. Halting this metabolism could hamper pivotal functions in the plant host, including cell wall synthesis and lesion repair. In conclusion, our findings indicate that altered metabolic responses that occur during fungal parasitism can cause deficiency in substrates in pivotal pathways and thereby trigger pathological symptoms.
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