ArticleNature communications2016
Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 93 citations in OpenAlex.
- Total Synthesis of Feglymycin Using Umpolung Amide Synthesis.Angewandte Chemie (International ed. in English) · 2025Article
- Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines.Signal transduction and targeted therapy · 2025Review
- Straightforward, scalable, solution-phase synthesis of peptide bonds in flow.Journal of flow chemistry · 2025Article
- Synthetic ramoplanin analogues are accessible by effective incorporation of arylglycines in solid-phase peptide synthesis.Chemical science · 2023Article
- Rapid and column-chromatography-free peptide chain elongationChemical science · 2023Article
- Trimethylaluminum-mediated one-pot peptide elongation.Chemical science · 2023Article
- Verification of preparations of (1H-indol-3-yl)methyl electrophiles and development of their microflow rapid generation and substitution.Communications chemistry · 2023Article
- Chemical Wastes in the Peptide Synthesis Process and Ways to Reduce Them.Iranian journal of pharmaceutical research : IJPR · 2022Review
- Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution.ChemSusChem · 2022Review
- Greening the synthesis of peptide therapeutics: an industrial perspective.RSC advances · 2020Review
- Article
- Targeted Gene Delivery into Various Plastids Mediated by Clustered Cell-Penetrating and Chloroplast-Targeting Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Chemodivergent synthesis ofRSC advances · 2019Article
- Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides.Nature communications · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes highly racemizable 3,5-dihydroxyphenylglycines (Dpgs). Here we describe the total synthesis of feglymycin based on a linear/convergent hybrid approach. Our originally developed micro-flow amide bond formation enabled highly racemizable peptide chain elongation based on a linear approach that was previously considered impossible. Our developed approach will enable the practical preparation of biologically active oligopeptides that contain highly racemizable amino acids, which are attractive drug candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.