ArticleJournal of the American Geriatrics Society2017
Changes in Drug Use and Polypharmacy After the Age of 90: A Longitudinal Study of the Danish 1905 Cohort.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Trial
- Article
- The Prevalence of Polypharmacy and the Contribution of Age, Period, and Cohort Effects in Sweden From 2006 to 2020.Health science reports · 2025Article
- Increase in Chronic Medications and Polypharmacy-The Multifaceted Burden of COVID-19 Disease on Public Health Care.Journal of personalized medicine · 2023Article
- Factors associated with polypharmacy and the high risk of medication-related problems among older community-dwelling adults in European countries: a longitudinal study.BMC geriatrics · 2022Article
- Is polypharmacy associated with mortality in the very old: Findings from the Newcastle 85+ Study.British journal of clinical pharmacology · 2022Article
- Article
- The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review.Therapeutic advances in drug safety · 2022Review
- Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- The epidemiology of polypharmacy in older adults: register-based prospective cohort study.Clinical epidemiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo determine the longitudinal development of drug use in very old adults.
designLongitudinal cohort study with waves in 1998, 2000, 2002, and 2005.
settingNationwide study in Denmark.
participantsAll living Danes born in 1905 were approached in 1998; 2,262 responded at baseline. MEASUREMENTS: Self-reported use of regularly taken drugs. Mean and median number of drugs and growth curve models were used to identify the change in number of drugs as the cohort aged from 92 to 100.
resultsThe within-person use of drugs increased with age for women (0.19 per year; 95% confidence interval (CI) = 0.15-0.24) and men (0.15 per year; 95% CI = 0.06-0.24). Persons leaving the study prematurely had higher baseline values and a steeper increase in their annual use of drugs. The population-level mean number of drugs increased from baseline (3.6 drugs) to the first follow-up (4.1 drugs) but thereafter remained stable at approximately 4 drugs. Women used more drugs than men at all waves.
conclusionIn this first longitudinal study of drug use in nonagenarians, individuals used an increasing number of drugs as they aged. This increase is difficult to detect in cross-sectional analyses of the population-level mean. More efforts to understand what is reasonable prescribing at these older ages are needed.
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