Evidence map›Paper›PMID 27890929›Full record

ArticleLeukemia2017

Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftment.

S Kim, L Lin, G A J Brown, K Hosaka, E W Scott

Open access · greenAbstract read
In one paragraph

Article in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Reduction of leukemic burden via bone-targeted nanoparticle delivery of an inhibitor of C-chemokine (C-C motif) ligand 3 (CCL3) signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  8. Review
  9. Review
  10. Intravital imaging of orthotopic and ectopic bone.Inflammation and regeneration · 2020
    Review
  11. Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. The Bone Marrow Microenvironment in Health and Myeloid Malignancy.Cold Spring Harbor perspectives in medicine · 2018
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

S KimProgram in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
L LinProgram in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
G A J BrownProgram in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
K HosakaDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
E W ScottProgram in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
University of Florida · USFlorida College · US

Funding

Adult HSC Provide 'Hemangioblast'ActivityR01HL070738 · NHLBI · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2002 to 2011
$2.9M
Adult Hemangioblast/HSC Recruitment and MaintenanceR01HL075258 · NHLBI · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2006 to 2009
$1.8M
NHLBI NIH HHS R01 HL070738NHLBI NIH HHS R01 HL075258
6 · The paper itself

Abstract

Homing, engraftment and proliferation of hematopoietic stem/progenitor cell (HSC/HPCs) are crucial steps required for success of a bone marrow transplant. Observation of these critical events is limited by the opaque nature of bone. Here we demonstrate how individual HSCs engraft in long bones by thinning one side of the tibia for direct and unbiased observation. Intravital imaging enabled detailed visualization of single Sca-1

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsBone Marrow CellsCell MovementCell ProliferationMiceMice, Inbred C57BLOsteopontinStem Cell NicheTibiaOsteopontin

Identifiers

PMID27890929
PMCPMC5498248
OpenAlexW2558098939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.