Evidence map›Paper›PMID 27890922›Full record

ReviewNature reviews. Microbiology2017

Progress in imaging methods: insights gained into Plasmodium biology.

Mariana De Niz, Paul-Christian Burda, Gesine Kaiser, Hernando A Del Portillo, Tobias Spielmann, Freddy Frischknecht, Volker T Heussler

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Identification of a conserved gene family with an essential role inProceedings of the National Academy of Sciences of the United States of America · 2026
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  16. Labeling Strategies for Surface-Exposed Protein Visualization and Determination inFrontiers in cellular and infection microbiology · 2022
    Article
  17. Article
  18. Methods Used to Investigate theFrontiers in cellular and infection microbiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariana De NizInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Paul-Christian BurdaInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Gesine KaiserInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
Hernando A Del PortilloCatalan Institution for Research and Advanced Studies (ICREA) at Barcelona Institute for Global Health (ISGlobal), Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain.
Tobias SpielmannBernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany.
Freddy FrischknechtParasitology, Center for Infectious Diseases, Heidelberg University School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
Volker T HeusslerInstitute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decade, major advances in imaging techniques have enhanced our understanding of Plasmodium spp. parasites and their interplay with mammalian hosts and mosquito vectors. Cryoelectron tomography, cryo-X-ray tomography and super-resolution microscopy have shifted paradigms of sporozoite and gametocyte structure, the process of erythrocyte invasion by merozoites, and the architecture of Maurer's clefts. Intravital time-lapse imaging has been revolutionary for our understanding of pre-erythrocytic stages of rodent Plasmodium parasites. Furthermore, high-speed imaging has revealed the link between sporozoite structure and motility, and improvements in time-lapse microscopy have enabled imaging of the entire Plasmodium falciparum erythrocytic cycle and the complete Plasmodium berghei pre-erythrocytic stages for the first time. In this Review, we discuss the contribution of key imaging tools to these and other discoveries in the malaria field over the past 10 years.

Indexed as

AnimalsCryoelectron MicroscopyElectron Microscope TomographyErythrocytesHost-Parasite InteractionsHumansMalariaMerozoitesPlasmodium bergheiPlasmodium falciparumSporozoitesTime-Lapse Imaging

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.