Evidence map›Paper›PMID 27890795›Full record

ArticleThe international journal of biochemistry & cell biology2017

Inhibition of histone/lysine acetyltransferase activity kills CoCl

Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixit, Niranjan Rout, Shivaram P Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T Smoot and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of biochemistry & cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Suvasmita RathSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Lopamudra DasSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Shrikant Babanrao KokateSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Nilabh GhoshSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Pragyesh DixitSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Niranjan RoutOncopathology, Acharya Harihar Regional Cancer Centre, Cuttack, 753007, Odisha, India.
Shivaram P SinghDepartment of Gastroenterology, SCB Medical College, Cuttack, 753007, Odisha, India.
Subhasis ChattopadhyaySchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India.
Hassan AshktorabDepartment of Medicine, Howard University, Washington, DC, 20059, USA.
Duane T SmootDepartment of Medicine, Meharry Medical Center, Nashville, TN, 37208, USA.
Mahadeva M SwamyTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Jakkur PO, Bangalore 560064, Karnataka, India.
Tapas K KunduTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Jakkur PO, Bangalore 560064, Karnataka, India.
Sheila E CroweSchool of Medicine, University of California, San Diego, CA, 92093, USA.
Asima BhattacharyyaSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, 752050, Odisha, India. Electronic address: asima@niser.ac.in.
National Institute of Science Education and Research · INJawaharlal Nehru Centre for Advanced Scientific Research · INHoward University · USMeharry Medical College · USRegional Cancer Center, Thiruvananthapuram · INSriram Chandra Bhanja Medical College Hospital · INUniversity of California, San Diego · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

Hypoxia enhances immortality and metastatic properties of solid tumors. Deregulation of histone acetylation has been associated with several metastatic cancers but its effect on hypoxic responses of cancer cells is not known. This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl

Indexed as

AcetylationAntineoplastic AgentsApoptosisCell Line, TransformedCell Line, TumorCobaltCurcuminE1A-Associated p300 ProteinEnzyme InhibitorsGastric MucosaGene Expression Regulation, NeoplasticHumansHydrazinesHydrogen PeroxideMAP Kinase Signaling SystemNeoplasm InvasivenessAntineoplastic AgentsCobaltcobaltous chlorideCurcuminE1A-Associated p300 ProteinEnzyme InhibitorsEP300 protein, humanHydrazineshydrazinocurcuminHydrogen PeroxideReactive Oxygen SpeciesApoptosisCancer metastasisCTK7AHATHif1αHypoxia

Identifiers

PMID27890795
PMCPMC5718055
OpenAlexW2553514617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.