Evidence map›Paper›PMID 27890646›Full record

ArticleAmerican journal of obstetrics and gynecology2017

Laparoscopic hysterectomy with morcellation vs abdominal hysterectomy for presumed fibroids: an updated decision analysis following the 2014 Food and Drug Administration safety communications.

Matthew T Siedhoff, Kemi M Doll, Daniel L Clarke-Pearson, Sarah E Rutstein

Abstract readComparative Study
In one paragraph

Article in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. UTERINE FIBROIDS.Physiological reviews · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
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  18. Article
  19. Association Between Power Morcellation and Mortality in Women With Unexpected Uterine Cancer Undergoing Hysterectomy or Myomectomy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Matthew T SiedhoffCenter for Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: Matthew.Siedhoff@cshs.org.
Kemi M DollDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA.
Daniel L Clarke-PearsonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.
Sarah E RutsteinDepartment of Health Policy and Management, School of Medicine, University of North Carolina, Chapel Hill, NC.
University of North Carolina at Chapel Hill · USCedars-Sinai Medical Center · USUniversity of Washington · US

Funding

Cancer Training GrantR25CA116339 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BASCH, ETHAN M., REEVE, BRYCE B · 2008 to 2017
$4.0M
NCI NIH HHS R25 CA116339
6 · The paper itself

Abstract

Previous decision analyses demonstrate the safety of minimally invasive hysterectomy for presumed benign fibroids, accounting for the risk of occult leiomyosarcoma and the differential mortality risk associated with laparotomy. Studies published since the 2014 Food and Drug Administration safety communications offer updated leiomyosarcoma incidence estimates. Incorporating these studies suggests that mortality rates are low following hysterectomy for presumed benign fibroids overall, and a minimally invasive approach remains a safe option. Risk associated with morcellation, however, increases in women age >50 years due to increased leiomyosarcoma rates, an important finding for patient-centered discussions of treatment options for fibroids.

Indexed as

LaparoscopyMorcellationDecision Support TechniquesDecision TreesFemaleHumansHysterectomyLeiomyomaLeiomyosarcomaMiddle AgedNeoplasms, Multiple PrimaryUnited StatesUnited States Food and Drug AdministrationUterine Neoplasmsdecision-analysisfibroidhysterectomylaparoscopyleiomyomaleiomyosarcomamorcellationmortalitymyoma

Identifiers

PMID27890646
PMCPMC5835972
OpenAlexW2553691126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.