Evidence map›Paper›PMID 27890235›Full record

ReviewDermatologic clinics2017

Dermatologic Manifestations of Monogenic Autoinflammatory Diseases.

Kyawt Win Shwin, Chyi-Chia Richard Lee, Raphaela Goldbach-Mansky

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dermatologic clinics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Cutaneous vasculitis in autoinflammatory diseases.The Journal of dermatology · 2024
    Review
  6. Article
  7. Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases.JID innovations : skin science from molecules to population health · 2023
    Review
  8. Panniculitis in Children.Dermatopathology (Basel, Switzerland) · 2021
    Review
  9. Review
  10. Article
  11. [Clinical symptoms of autoinflammatory diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020
    Review
  12. A Novel BiallelicFrontiers in immunology · 2020
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kyawt Win ShwinTranslational Autoinflammatory Disease Studies, Rheumatology Fellowship Program, National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Building 10, Room 6D-52, 10 Center Drive, Bethesda, MD 20892, USA; Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas VA Medical Center, North Texas Health Care System, 4500 S. Lancaster Road, Dallas, TX 75216, USA.
Chyi-Chia Richard LeeDermatopathology Section, Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 2S235J, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Raphaela Goldbach-ManskyTranslational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Building 10, Room 6D-47B, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: goldbacr@mail.nih.gov.
Center for Cancer Research · USNational Institute of Allergy and Infectious Diseases · USThe University of Texas Southwestern Medical Center · US

Funding

Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Stills-like Diseases, and other Undifferentiated Autoinflammatory DiseasesZIAAI001220 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2017 to 2025
$22.3M
Pathogenesis and treatment studies in patients with NOMID and related diseasesZIAAR041138 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2009 to 2016
$8.6M
Intramural NIH HHS ZIA AR041138
6 · The paper itself

Abstract

Autoinflammatory disorders are sterile inflammatory conditions characterized by episodes of early-onset fever, rash, and disease-specific patterns of organ inflammation. Gain-of-function mutations in innate danger-sensing pathways, including the inflammasomes and the nucleic acid sensing pathways, play critical roles in the pathogenesis of IL-1 and Type-I IFN-mediated disorders and point to an important role of excessive proinflammatory cytokine signaling, including interleukin (IL)-1b , Type-I interferons, IL-18, TNF and others in causing the organ specific immune dysregulation. The article discusses the concept of targeting proinflammatory cytokines and their signaling pathways with cytokine blocking treatments that have been life changing for some patients.

Indexed as

Adrenal Cortex HormonesAnemia, Dyserythropoietic, CongenitalAntirheumatic AgentsAutoimmune DiseasesColchicineHereditary Autoinflammatory DiseasesHumansImmunologic Deficiency SyndromesInterleukin-1Interleukin-18Interleukin 1 Receptor Antagonist ProteinMacrophage Activation SyndromeOsteomyelitisSkin DiseasesTubulin ModulatorsTumor Necrosis Factor-alphaAdrenal Cortex HormonesAntirheumatic AgentsColchicineInterleukin-1Interleukin-18Interleukin 1 Receptor Antagonist ProteinTubulin ModulatorsTumor Necrosis Factor-alphaAutoinflammatory disordersIL-1Immune dysregulationNeutrophilic dermatosesPanniculitisType I interferonurticaria

Identifiers

PMID27890235
PMCPMC5147585
OpenAlexW2555339240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.