ReviewDermatologic clinics2017
Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything.
Review in Dermatologic clinics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Exploring the impact of IL-2 cytokine family on skin barrier function: pathophysiology and therapeutic strategies.Molecular biology reports · 2026Review
- Beyond the skin barrier: commensalbioRxiv : the preprint server for biology · 2026Article
- Atopic diseases in pediatric population: prematurity and small for gestational age.BMC pediatrics · 2025Article
- An in silico approach deciphering the commensal dynamics in the cutaneous milieu.NPJ systems biology and applications · 2025Article
- Symbiotic bacteria-mediated imbalance and repair of immune homeostasis: exploring novel mechanisms of microbiome-host interactions in atopic dermatitis.Frontiers in immunology · 2025Review
- Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma.Experimental dermatology · 2023Article
- Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life.Brain sciences · 2023Article
- Atopic dermatitis and gestational age - is there an association between them? A review of the literature and an analysis of pathology.Postepy dermatologii i alergologii · 2023Review
- Recent advances in epicutaneous immunotherapy and potential applications in food allergy.Frontiers in allergy · 2023Review
- Neonatal sepsis and the skin microbiome.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
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- Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9.Science immunology · 2021Article
- Characterization of Ocular Surface Microbial Profiles Revealed Discrepancies between Conjunctival and Corneal Microbiota.Pathogens (Basel, Switzerland) · 2021Article
- Duration of neonatal intensive care unit exposure associated with decreased risk of atopic dermatitis.Pediatric dermatology · 2021Article
- Revealing the secret life of skin - with the microbiome you never walk alone.International journal of cosmetic science · 2020Review
- Lung microbiome - a modern knowledge.Central-European journal of immunology · 2020Review
- Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata.Frontiers in cellular and infection microbiology · 2020Article
- The exposome in atopic dermatitis.Allergy · 2020Review
- Brown Adipocyte and Splenocyte Co-Culture Maintains Regulatory T Cell Subset in Intermittent Hypobaric Conditions.Tissue engineering and regenerative medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found that colonization during neonatal but not adult life led to S.epidermidis-specific immune tolerance. This tolerance protected against skin inflammation and was mediated by a wave of regulatory T cells entering neonatal skin. These findings provide new insight into how we establish a healthy symbiosis with commensal microbes and highlight avenues for future research to identify novel therapies for inflammatory skin disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.