Evidence map›Paper›PMID 27890016›Full record

ReviewCritical care (London, England)2016

The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology.

Jonathan E Millar, Jonathon P Fanning, Charles I McDonald, Daniel F McAuley, John F Fraser

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 384 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
384citing papers in PubMed, 8 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

384 citing papers in PubMed, 8 syntheses or guidelines pooled it, 752 citations in OpenAlex.

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324 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jonathan E MillarCritical Care Research Group, University of Queensland, Brisbane, Australia. j.millar@doctors.org.uk.
Jonathon P FanningCritical Care Research Group, University of Queensland, Brisbane, Australia.
Charles I McDonaldCritical Care Research Group, University of Queensland, Brisbane, Australia.
Daniel F McAuleyWellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK.
John F FraserCritical Care Research Group, University of Queensland, Brisbane, Australia.
University of Queensland · AUQueen's University Belfast · GB

Funding

Department of Health HTA/13/143/02
6 · The paper itself

Abstract

Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-term mechanical support to the heart, lungs or both. Over the last decade, the number of centres offering ECMO has grown rapidly. At the same time, the indications for its use have also been broadened. In part, this trend has been supported by advances in circuit design and in cannulation techniques. Despite the widespread adoption of extracorporeal life support techniques, the use of ECMO remains associated with significant morbidity and mortality. A complication witnessed during ECMO is the inflammatory response to extracorporeal circulation. This reaction shares similarities with the systemic inflammatory response syndrome (SIRS) and has been well-documented in relation to cardiopulmonary bypass. The exposure of a patient's blood to the non-endothelialised surface of the ECMO circuit results in the widespread activation of the innate immune system; if unchecked this may result in inflammation and organ injury. Here, we review the pathophysiology of the inflammatory response to ECMO, highlighting the complex interactions between arms of the innate immune response, the endothelium and coagulation. An understanding of the processes involved may guide the design of therapies and strategies aimed at ameliorating inflammation during ECMO. Likewise, an appreciation of the potentially deleterious inflammatory effects of ECMO may assist those weighing the risks and benefits of therapy.

Indexed as

Extracorporeal Membrane OxygenationHumansImmunity, InnateSystemic Inflammatory Response SyndromeCoagulationECMOExtracorporeal membrane oxygenationInflammationSIRS

Identifiers

PMID27890016
PMCPMC5125043
OpenAlexW2550402311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.