ReviewCurrent hypertension reports2016
How to Screen for Non-Adherence to Antihypertensive Therapy.
Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Nurse's Contribution to Alleviate Non-adherence to Hypertension Treatment.Current hypertension reports · 2018Pooled it
- Achieving optimal adherence to medical therapy by telehealth: Findings from the ORBITA medication adherence sub-study.Pharmacology research & perspectives · 2021Trial
- Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP):: A Randomized Double-Blind Placebo-Controlled Feasibility Trial.Hypertension (Dallas, Tex. : 1979) · 2020Trial
- A literature review of the pharmacokinetic profiles of 20 commonly prescribed antihypertensive medications for use in chemical adherence testing.Journal of hypertension · 2026Review
- Clinician's attitudes & perspective on chemical adherence testing in hypertension (CATCH): A qualitative interview study.British journal of clinical pharmacology · 2026Article
- Medication non-adherence and apparent treatment-resistant hypertension.Clinical medicine (London, England) · 2026Review
- Chemical adherence testing-guided intervention versus standard of care in patients with hypertension who are non-adherent to antihypertensive treatment in the UK (OUTREACH): a multicentre, randomised controlled trial.The Lancet. Primary care · 2026Article
- Cardiovascular medication adherence testing in patients living with HIV: A single-centre observational study.HIV medicine · 2024Observational
- Translation, transcultural adaptation, and validation of the Brazilian Portuguese version of the general medication adherence scale (GMAS) in patients with high blood pressure.Exploratory research in clinical and social pharmacy · 2024Article
- May Measure Month 2022 in Italy: A Focus on Fixed-dose Combination, Therapeutic Adherence, and Medical Inertia in a Nationwide Survey.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Improved Persistence to Medication, Decreased Cardiovascular Events and Reduced All-Cause Mortality in Hypertensive Patients With Use of Single-Pill Combinations: Results From the START-Study.Hypertension (Dallas, Tex. : 1979) · 2023Article
- [Use of Multiple Methods to Measure Adherence to Antiretroviral Treatment in La Romana, Dominican RepublicMedição da adesão a antirretrovirais com múltiplos métodos em La Romana, República Dominicana].Revista panamericana de salud publica = Pan American journal of public health · 2022Article
- Real-world Antihypertensive Treatment Patterns, Treatment Adherence, and Blood Pressure Control in the Elderly: An Italian Awareness-raising Campaign on Hypertension by Senior Italia FederAnziani, the Italian Society of Hypertension and the Italian Federation of General Practitioners.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Article
- Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries.International journal of cardiology. Cardiovascular risk and prevention · 2021Article
- Early adherence to antihypertensive drugs and long-term cardiovascular mortality in the "real world".Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography-tandem mass spectrometry-based urine analysis.European heart journal. Cardiovascular pharmacotherapy · 2021Article
- Urine Concentration Does Not Affect Biochemical Testing for Non-adherence.Journal of analytical toxicology · 2021Article
- Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis.Molecules (Basel, Switzerland) · 2021Article
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Clarification of the Correct Nomenclature of the Amino Metabolite of Clonazolam: 8-Aminoclonazolam.Journal of analytical toxicology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians' perceptions are inaccurate, and questionnaires completed by patients tend to overreport adherence and show a low diagnostic specificity. Indirect objective methods such as pharmacy database records can be useful, but they are limited by the robustness of the recorded data. Electronic medication monitoring devices are accurate but usually track adherence to only a single medication and can be expensive. Overall, the fundamental issue with indirect objective measures is that they do not fully confirm ingestion of antihypertensive medications. Detection of antihypertensive medications in body fluids using liquid chromatography-tandem mass spectrometry is currently, in our view, the most robust and clinically useful method to assess non-adherence to blood-pressure-lowering treatment. It is particularly helpful in patients presenting with resistant, refractory or uncontrolled hypertension despite the optimal therapy. We recommend using this diagnostic strategy to detect non-adherence alongside a no-blame approach tailoring support to address the perceptions (e.g. beliefs about the illness and treatment) and practicalities (e.g. capability and resources) influencing motivation and ability to adhere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.