Evidence map›Paper›PMID 27889884›Full record

ArticleJournal of molecular modeling2016

Reduced density gradient as a novel approach for estimating QSAR descriptors, and its application to 1, 4-dihydropyridine derivatives with potential antihypertensive effects.

Christiaan Jardínez, Alberto Vela, Julián Cruz-Borbolla, Rodrigo J Alvarez-Mendez, José G Alvarado-Rodríguez

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christiaan JardínezÁrea Académica de Química, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Hidalgo, km. 4.5 Carretera Pachuca-Tulancingo, Ciudad del Conocimiento, C.P. 42184, Mineral de la Reforma, Hidalgo, Mexico.
Alberto VelaDepartamento de Química, Centro de Investigación y de Estudios Avanzados (Cinvestav), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07360, México, D.F., Mexico.
Julián Cruz-BorbollaÁrea Académica de Química, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Hidalgo, km. 4.5 Carretera Pachuca-Tulancingo, Ciudad del Conocimiento, C.P. 42184, Mineral de la Reforma, Hidalgo, Mexico. jcruz@uaeh.edu.mx.
Rodrigo J Alvarez-MendezDepartamento de Química, Centro de Investigación y de Estudios Avanzados (Cinvestav), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07360, México, D.F., Mexico.
José G Alvarado-RodríguezÁrea Académica de Química, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Hidalgo, km. 4.5 Carretera Pachuca-Tulancingo, Ciudad del Conocimiento, C.P. 42184, Mineral de la Reforma, Hidalgo, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between the chemical structure and biological activity (log IC

Indexed as

Models, MolecularQuantitative Structure-Activity RelationshipAntihypertensive AgentsDihydropyridinesHydrogen BondingMolecular ConformationMolecular StructureQuantum TheoryAntihypertensive AgentsDihydropyridines1,4-dihydropyridineDensity functional theory calculationQSARReduced density gradient

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.