Evidence map›Paper›PMID 27889877›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017

MALDI-TOF MS meets WGS in a VRE outbreak investigation.

S Schlebusch, G R Price, R L Gallagher, V Horton-Szar, L D H Elbourne, P Griffin, D J Venter, S O Jensen, S J Van Hal

Abstract read
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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Exploring the Utility of MALDI-TOF Mass Spectrometry and Antimicrobial Resistance in Hospital Outbreak Detection.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
  4. Article
  5. Review
  6. Systematic review of healthcare-associatedInfection prevention in practice · 2020
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Bacterial genome sequencing in clinical microbiology: a pathogen-oriented review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S SchlebuschPathology Department, Mater Health Services, South Brisbane, QLD, Australia. sanmarie.schlebusch@mater.org.au.
G R PricePathology Department, Mater Health Services, South Brisbane, QLD, Australia.
R L GallagherPathology Department, Mater Health Services, South Brisbane, QLD, Australia.
V Horton-SzarPathology Department, Mater Health Services, South Brisbane, QLD, Australia.
L D H ElbourneDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
P GriffinSchool of Medicine, The University of Queensland, St Lucia, Australia.
D J VenterPathology Department, Mater Health Services, South Brisbane, QLD, Australia.
S O JensenMolecular Medicine Research Group, School of Medicine, Western Sydney University, Sydney, NSW, Australia.
S J Van HalDepartment of Microbiology and Infectious Diseases, Royal Prince Alfred Hospital, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of MALDI-TOF MS (matrix-assisted laser desorption/ ionization-time of flight mass spectrometry) and WGS (whole genome sequencing) has been described for identification and strain relatedness determination. We describe the complementary use of MALDI-TOF MS and WGS in a VRE (vancomycin-resistant enterococci) outbreak investigation, and discuss some of the challenges with defining strain similarity across these two platforms. Although both assays indicated multiple clusters involved in the outbreak of vancomycin resistant Enterococcus faecium isolates from positive blood cultures of four haematology-oncology patients, the small cohort and discrepancies between findings indicate the limitations of MALDI-TOF MS and the cautious interpretation of MALDI-TOF MS dendrograms during outbreaks. For definitive determination of the evolutionary distance between isolates, WGS can be used.

Indexed as

Disease OutbreaksBacteremiaBacterial Typing TechniquesEnterococcus faeciumGram-Positive Bacterial InfectionsHigh-Throughput Nucleotide SequencingHumansMolecular EpidemiologySequence Analysis, DNASpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationVancomycin-Resistant Enterococci

Identifiers

PMID27889877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.