ArticleJournal of bioenergetics and biomembranes2016
The function of activatable cell-penetrating peptides in human intrahepatic bile duct epithelial cells.
Article in Journal of bioenergetics and biomembranes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Targeting and imaging colorectal cancer by activatable cell-penetrating peptides.American journal of translational research · 2020Article
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Authors and funding
6 authors.
Funding
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Abstract
This study aimed to investigate the function of Activatable Cell-Penetrating Peptides (ACPP) in detecting the changes of human intrahepatic bile duct epithelial cell(hIBDEC). ACPP, which target matrix metalloproteinases, were constructed. All were labeled with FITC and Gd-DTPA at the N-terminal. Fluorescence microscopy was used to observe the fluorescence intensity inside hIBDEC after stimulating with different concentrations of LPS and incubating with different concentrations of ACPP to determine the optimal concentration range for LPS stimulation and the optimal concentration for FITC-ACPP effect. Flow cytometry and magnetic resonance imaging were used to detect fluorescence signal intensity and nuclear magnetic resonance signal intensity, respectively, after stimulating with different concentrations of LPS. LPS stimulation time and ACPP incubation time were also evaluated, and variance analysis was conducted to analyze intracellular signal change characteristics for every group. Activatable Cell-Penetrating Peptides (ACPP), which were marked with FITC and Gd-DTPA had target-penetrating activity. The intracellular signal intensity gradually increased with the increase in LPS stimulation time and ACPP incubation time within a certain range; however, it did not increase with the increase of LPS concentration. ACPP can be used for imaging hIBDEC with epithelial-mesenchymal transition.
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Registered trials
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