ArticleAging2016
Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster.Genetics · 2023Article
- The hunger strikes back: an epigenetic memory for autophagy.Cell death and differentiation · 2023Review
- Article
- Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions.Communications biology · 2022Article
- A genome-wide test for paternal indirect genetic effects on lifespan inProceedings. Biological sciences · 2022Article
- Metformin: A Potential Candidate for Targeting Aging Mechanisms.Aging and disease · 2021Review
- Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart.Nutrients · 2020Article
- Review
- Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology.Scientific reports · 2019Article
- Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance.BMC biology · 2018Article
- Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues.International journal of molecular sciences · 2018Article
- Environmentally induced epigenetic transgenerational inheritance of disease.Environmental epigenetics · 2018Review
- Developmental Tuning of Epigenetic Clock.Frontiers in genetics · 2018Article
- A 'phenotypic hangover': the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome ofEnvironmental epigenetics · 2017Article
- Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species.Epigenetics & chromatin · 2017Review
- Curcumin Induces Transgenerational and Sex-Specific Effects on Lifespan, Gene Expression, and Metabolism in the Fruit Fly Drosophila melanogaster.BioFactors (Oxford, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Transgenerational effects on health and development of early-life nutrition have gained increased attention recently. However, the underlying mechanisms of transgenerational transmission are only starting to emerge, with epigenetics as perhaps the most important mechanism. We recently reported the first animal model to study transgenerational programming of longevity after early-life dietary manipulations, enabling investigations to identify underlying epigenetic mechanisms. We report here that post-eclosion dietary manipulation (PDM) with a low-protein (LP) diet upregulates the protein level of E(z), an H3K27 specific methyltransferase, leading to higher levels of H3K27 trimethylation (H3K27me3). This PDM-mediated change in H3K27me3 corresponded with a shortened longevity of F0 flies as well as their F2 offspring. Specific RNAi-mediated post-eclosion knockdown of E(z) or pharmacological inhibition of its enzymatic function with EPZ-6438 in the F0 parents improved longevity while rendering H3K27me3 low across generations. Importantly, addition of EPZ-6438 to the LP diet fully alleviated the longevity-reducing effect of the LP PDM, supporting the increased level of E(z)-dependent H3K27me3 as the primary cause and immediate early-life period as the critical time to program longevity through epigenetic regulation. These observations establish E(z)-mediated H3K27me3 as one epigenetic mechanism underlying nutritional programming of longevity and support the use of EPZ-6438 to extend lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.