Evidence map›Paper›PMID 27889625›Full record

ReviewCurrent opinion in neurobiology2017

Cortical interneuron specification: the juncture of genes, time and geometry.

Rachel C Bandler, Christian Mayer, Gord Fishell

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 133 citations in OpenAlex.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rachel C BandlerNYU Neuroscience Institute, Langone Medical Center, New York, NY, USA.
Christian MayerNYU Neuroscience Institute, Langone Medical Center, New York, NY, USA.
Gord FishellNYU Neuroscience Institute, Langone Medical Center, New York, NY, USA. Electronic address: fisheg01@nyumc.org.
NYU Langone Health · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2M
The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2012 to 2023
$15.5M
The Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6M
FoxG1 in the Development of Cerebral Cortex and the Adult Neural Niche.R01MH095147 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHELL, GORDON J · 2012 to 2013
$1.2M
The genetic logic of interneuron differentiationF30MH114462 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BANDLER, RACHEL · 2017 to 2018
$84k
NIGMS NIH HHS T32 GM007308NIMH NIH HHS F30 MH114462NIMH NIH HHS R01 MH095147NINDS NIH HHS P01 NS074972NINDS NIH HHS R01 NS081297
6 · The paper itself

Abstract

A fundamental question in developmental neuroscience is how hundreds of diverse cell types are generated to form specialized brain regions. The ganglionic eminences (GEs) are embryonic brain structures located in the ventral telencephalon that produce many inhibitory GABA (γ-Aminobutyric acid)-ergic cell types, including long-range projection neurons and local interneurons (INs), which disperse widely throughout the brain. While much has been discovered about the origin and wiring of these cells, a major question remains: how do neurons originating in the GEs become specified during development as one differentiated subtype versus another? This review will cover recent work that has advanced our knowledge of the mechanisms governing cortical interneuron subtype specification, particularly progenitors' spatial origin, birthdates, lineage, and mode of division.

Indexed as

BrainCell DifferentiationHumansInterneuronsNeuronsTelencephalon

Identifiers

PMID27889625
PMCPMC5699457
OpenAlexW2554588614

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.