SynthesisArchives of gerontology and geriatrics
Adverse events and treatment discontinuations of antimuscarinics for the treatment of overactive bladder in older adults: A systematic review and meta-analysis.
Synthesis in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07710794 (Transcutaneous Tibial Nerve Stimulation), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcutaneous Tibial Nerve Stimulation (TTNS) Patch Combined With Behavioral Therapy (BT) Versus Behavioral Therapy in the Treatment of Patients With Lower Urinary Tract Symptoms (LUTS) After Benign Prostatic Hyperplasia (BPH) Surgery: a Prospective, Randomized Controlled Study
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Efficacy and safety of vaginal electrical stimulation as an alternative or adjunct treatment for overactive bladder syndrome in women: a meta-analysis of randomized controlled trials.International urogynecology journal · 2023Pooled it
- The use of mirabegron in neurogenic bladder: a systematic review.World journal of urology · 2020Pooled it
- Pooled it
- Thread Embedding Acupuncture in Postmenopausal Women with Overactive Bladder: A Prospective, Single-Arm, Before-After Study.International journal of women's health · 2024Trial
- Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility.Respirology (Carlton, Vic.) · 2022Trial
- Different antimuscarinics when combined with atomoxetine have differential effects on obstructive sleep apnea severity.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Efficacy of novel βInternational journal of urology : official journal of the Japanese Urological Association · 2019Trial
- Clinical predictors of symptom and quality-of-life improvement with antimuscarinics in overactive bladder: a 12-month prospective cohort study in Türkiye.BMC urology · 2026Observational
- Thread-Embedding versus Manual Acupuncture for Overactive Bladder in Postmenopausal Women: Randomized Controlled Trial.International journal of women's health · 2026Article
- Knockdown of FKBP12.6 may Cause Bladder Dysfunction in Mice by Affecting IP3R/TRPM4 Function.Current medicinal chemistry · 2026Article
- Effects ofFood science & nutrition · 2025Article
- Pharmacological Targeting of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels on Bladder Afferent Sensory Transmission.Lower urinary tract symptoms · 2025Article
- Effect of a novel implantable tibial nerve stimulation system on overactive bladder in pigs.Translational andrology and urology · 2025Article
- Comparative safety of antimuscarinics versus mirabegron for overactive bladder in Parkinson disease.Parkinsonism & related disorders · 2023Article
- Management of use of urinary antimuscarinics and alpha blockers for benign prostatic hyperplasia in older adults at risk of falls: a clinical review.European geriatric medicine · 2023Review
- Effectiveness of Fluid and Caffeine Modifications on Symptoms in Adults With Overactive Bladder: A Systematic Review.International neurourology journal · 2023Article
- Patients' Preferences and Expectations in Overactive Bladder: A Systematic Review.Journal of clinical medicine · 2023Review
- Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives.International journal of women's health · 2023Review
- Risk of delirium associated with antimuscarinics in older adults: A case-time-control study.Pharmacoepidemiology and drug safety · 2022Article
- A non-interventional cross-sectional re-contact study investigating the relationship between overactive bladder and frailty in older adults in Japan.BMC geriatrics · 2022Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAntimuscarinics should be used with caution in older adults with overactive bladder (OAB) due to anticholinergic adverse events (AEs). Systematic reviews and meta-analyses (SRMAs) have analyzed safety-related outcomes but have not specified risk in the elderly, the population at highest risk for AEs. The aim of this review is to explore and evaluate AEs and treatment discontinuations in adults 65 or older taking antimuscarinics for OAB.
methodsKeywords were searched in MEDLINE, EMBASE, SCOPUS, and Cochrane Central Register for Controlled Trials. Randomized controlled trials (RCTs) along with sub-analyses and pooled analyses that compared antimuscarinics to placebo or another antimuscarinic were performed in February 2015. Studies assessing AEs or treatment discontinuations in a population of adults 65 or older were included. The Jadad Criteria and McHarm Tool were used to assess the quality of the trials.
resultsA total of 16 studies met the inclusion criteria. Eighty AEs and 27 reasons for treatment discontinuation were described in the included studies and further explored. Anticholinergic AEs were more common in antimuscarinics compared to placebo. Incidence of dizziness, dyspepsia, and urinary retention with fesoterodine, headache with darifenacin, and urinary tract infections with solifenacin were significantly higher compared to placebo. Treatment discontinuation due to AEs and dry mouth were higher in the antimuscarinics when compared to placebo in older adults.
conclusionsTreatment for overactive bladder using antimuscarinics in adults aged 65 or older resulted in significant increases in risk for several AEs compared to placebo including anticholinergic and non-anticholinergic AEs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.