Evidence map›Paper›PMID 27889304›Full record

ArticleBiochimica et biophysica acta. Biomembranes2017

Distinct membrane properties are differentially influenced by cardiolipin content and acyl chain composition in biomimetic membranes.

Edward Ross Pennington, Amy Fix, E Madison Sullivan, David A Brown, Anthony Kennedy, Saame Raza Shaikh

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Edward Ross PenningtonDepartment of Biochemistry & Molecular Biology, USA; East Carolina Diabetes & Obesity Institute, Brody School of Medicine, East Carolina University, 115 Heart Drive, Mail Stop 743, Greenville, NC 27834, USA.
Amy FixDepartment of Biochemistry & Molecular Biology, USA.
E Madison SullivanDepartment of Biochemistry & Molecular Biology, USA; East Carolina Diabetes & Obesity Institute, Brody School of Medicine, East Carolina University, 115 Heart Drive, Mail Stop 743, Greenville, NC 27834, USA.
David A BrownDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech Corporate Research Center, 1035 ILSB, 1981 Kraft Drive, Blacksburg, VA 24060, USA.
Anthony KennedyDepartment of Chemistry, East 10th Street, Mail Stop 552, East Carolina University, Greenville, NC 27854, USA.
Saame Raza ShaikhDepartment of Biochemistry & Molecular Biology, USA; East Carolina Diabetes & Obesity Institute, Brody School of Medicine, East Carolina University, 115 Heart Drive, Mail Stop 743, Greenville, NC 27834, USA. Electronic address: shaikhsa@ecu.edu.
East Carolina University · USVirginia Cooperative Extension · US

Funding

Suppressing inflammation and boosting humoral immunity with n-3 PUFAsR01AT008375 · NCCIH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHAIKH, SAAME R · 2015 to 2019
$1.9M
Mitochondrial respirasomes in acute coronary syndromesR01HL123647 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HULVER, MATTHEW W, SHAIKH, SAAME R · 2015 to 2018
$1.4M
Label-free RF Imaging of Cell Membrane Heterogeneity in LiquidK25GM100480 · NIGMS · CLEMSON UNIVERSITY · PI WANG, PINGSHAN · 2012 to 2016
$726k
Treatment of cardiac reperfusion injury by optimizing the mitochondrial membraneR15HL122922 · NHLBI · EAST CAROLINA UNIVERSITY · PI SHAIKH, SAAME R · 2015 to 2015
$434k
NCCIH NIH HHS R01 AT008375NHLBI NIH HHS R01 HL123647NHLBI NIH HHS R15 HL122922NIGMS NIH HHS K25 GM100480
6 · The paper itself

Abstract

Cardiolipin (CL) has a critical role in maintaining mitochondrial inner membrane structure. In several conditions such as heart failure and aging, there is loss of CL content and remodeling of CL acyl chains, which are hypothesized to impair mitochondrial inner membrane biophysical organization. Therefore, this study discriminated how CL content and acyl chain composition influenced select properties of simple and complex mitochondrial mimicking model membranes. We focused on monolayer excess area/molecule (a measure of lipid miscibility), bilayer phase transitions, and microdomain organization. In monolayer compression studies, loss of tetralinoleoyl [(18:2)

Indexed as

AnimalsBiomimeticsCardiolipinsCattleLipid BilayersMembrane MicrodomainsMembranesMitochondriaMitochondrial MembranesPhosphatidylcholinesTransition TemperatureUnilamellar LiposomesCardiolipinsLipid BilayersPhosphatidylcholinesUnilamellar LiposomesCardiolipinDocosahexaenoic acidMitochondriaMonolayersPressure-area isotherms

Identifiers

PMID27889304
PMCPMC5217480
OpenAlexW2552111517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.