Evidence map›Paper›PMID 27889021›Full record

ReviewNeuroimaging clinics of North America2017

Neuroimaging of Peptide-based Vaccine Therapy in Pediatric Brain Tumors: Initial Experience.

Andre D Furtado, Rafael Ceschin, Stefan Blüml, Gary Mason, Regina I Jakacki, Hideho Okada, Ian F Pollack, Ashok Panigrahy

Open access · greenAbstract readReview
In one paragraph

Review in Neuroimaging clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Andre D FurtadoDepartment of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA.
Rafael CeschinDepartment of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA; Department of Bioinformatics, University of Pittsburgh, 5607 Baum Boulevard, Suite 500, Pittsburgh, PA 15206, USA.
Stefan BlümlDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.
Gary MasonDepartment of Pediatrics, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
Regina I JakackiDepartment of Pediatrics, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
Hideho OkadaDepartment of Neurosurgery, University of California, San Francisco, 505 Parnassus Avenue, M-779, San Francisco, CA 94143, USA.
Ian F PollackDepartment of Neurosurgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA; Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
Ashok PanigrahyDepartment of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address: panigrahya@upmc.edu.
University of Pittsburgh · USUniversity of California, San Francisco · USUniversity of Southern California · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
Vector delivery to modify the brain tumor and its microenvironmentP01NS040923 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLLACK, IAN F. · 2002 to 2012
$12.7M
Peptide vaccine immunotherapy for children with recurrent low-grade astrocytomasR01CA187219 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLLACK, IAN F. · 2016 to 2020
$1.8M
Peptide-Based Vaccine Therapy for Childhood Malignant GliomasR21CA149872 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OKADA, HIDEHO, POLLACK, IAN F. · 2010 to 2011
$619k
NCATS NIH HHS UL1 TR000005NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA187219NCI NIH HHS R21 CA149872NCRR NIH HHS UL1 RR024153NINDS NIH HHS P01 NS040923NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

The potential benefits of peptide-based immunotherapy for pediatric brain tumors are under investigation. Treatment-related heterogeneity has resulted in radiographic challenges, including pseudoprogression. Conventional MR imaging has limitations in assessment of different forms of treatment-related heterogeneity, particularly regarding distinguishing true tumor progression from efficacious treatment responses. Advanced neuroimaging techniques, including diffusion magnetic resonance (MR), perfusion MR, and MR spectroscopy, may add value in the assessment of treatment-related heterogeneity. Observations suggest that recent delineation of specific response criteria for immunotherapy of adult brain tumors is likely relevant to the pediatric population and further validation in multicenter pediatric brain tumor peptide-based vaccine studies is warranted.

Indexed as

BrainBrain NeoplasmsChildDiffusion Magnetic Resonance ImagingHumansImmunotherapy, ActiveMagnetic Resonance ImagingMagnetic Resonance SpectroscopyNeuroimagingPeptidesTreatment OutcomePeptidesMR spectroscopyPediatric brain tumorsPseudoprogressionVaccine therapy

Identifiers

PMID27889021
PMCPMC5127439
OpenAlexW2559669314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.