ArticleJournal of affective disorders2017
Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis.Neuropsychology review · 2023Pooled it
- Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis.Translational psychiatry · 2022Pooled it
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- A Systematic Review of Studies Reporting Data-Driven Cognitive Subtypes across the Psychosis Spectrum.Neuropsychology review · 2020Pooled it
- Beyond Diagnosis: Transdiagnostic Cognitive Subgroups in Mood Disorders Linked to Work-Related Disability.Neuropsychopharmacology reports · 2026Article
- Social cognition abilities in people with HIV: the role of stigma and other factors.AIDS (London, England) · 2025Review
- Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach.Molecular psychiatry · 2025Article
- Do Cognitive Subtypes Exist in People at Clinical High Risk for Psychosis? Results From the EU-GEI Study.Schizophrenia bulletin · 2025Article
- Cognitive Correlates of Functional Disruption at Psychosis Onset: Unique Relevance of Visual Cognition.Journal of clinical medicine · 2025Article
- Neuropsychological profiles in first-episodes psychosis and their relationship with clinical, metacognition and social cognition variables.European archives of psychiatry and clinical neuroscience · 2025Article
- Impact of Anticholinergic Burden on Cognitive Functions in Individuals with Bipolar Disorder, Schizoaffective Disorder, and Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior.Journal of affective disorders · 2024Article
- Reading tea leaves or tracking true constructs? An assessment of personality-based latent profiles in eating disorders.Frontiers in psychiatry · 2024Article
- Efficacy of Functional Remediation on Cognitive and Psychosocial Functioning in Patients with Bipolar Disorder: Study Protocol for a Randomized Controlled Study.Brain sciences · 2023Article
- Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study.BJPsych open · 2022Article
- Characterization of Hemodynamic Alterations in Schizophrenia and Bipolar Disorder and Their Effect on Resting-State fMRI Functional Connectivity.Schizophrenia bulletin · 2022Article
- We both say tomato: Intact lexical alignment in schizophrenia and bipolar disorder.Schizophrenia research · 2022Article
- Characterising cognitive heterogeneity in individuals at clinical high-risk for psychosis: a cluster analysis with clinical and functional outcome prediction.European archives of psychiatry and clinical neuroscience · 2022Article
- Proteomic Analysis of Plasma Markers in Patients Maintained on Antipsychotics: Comparison to Patients Off Antipsychotics and Normal Controls.Frontiers in psychiatry · 2022Article
- Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
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8 authors.
Funding
Abstract
backgroundBipolar disorder (BD) and schizophrenia (SZ) show substantial overlap. It has been suggested that a subgroup of patients might contribute to these overlapping features. This study employed a cross-diagnostic cluster analysis to identify subgroups of individuals with shared cognitive phenotypes.
method143 participants (68 BD patients, 39 SZ patients and 36 healthy controls) completed a battery of EEG and performance assessments on perception, nonsocial cognition and social cognition. A K-means cluster analysis was conducted with all participants across diagnostic groups. Clinical symptoms, functional capacity, and functional outcome were assessed in patients.
resultsA two-cluster solution across 3 groups was the most stable. One cluster including 44 BD patients, 31 controls and 5 SZ patients showed better cognition (High cluster) than the other cluster with 24 BD patients, 35 SZ patients and 5 controls (Low cluster). BD patients in the High cluster performed better than BD patients in the Low cluster across cognitive domains. Within each cluster, participants with different clinical diagnoses showed different profiles across cognitive domains. LIMITATIONS: All patients are in the chronic phase and out of mood episode at the time of assessment and most of the assessment were behavioral measures.
conclusionsThis study identified two clusters with shared cognitive phenotype profiles that were not proxies for clinical diagnoses. The finding of better social cognitive performance of BD patients than SZ patients in the Lowe cluster suggest that relatively preserved social cognition may be important to identify disease process distinct to each disorder.
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