Evidence map›Paper›PMID 27888691›Full record

ArticleRedox biology2017

Redox imbalance and mitochondrial abnormalities in the diabetic lung.

Jinzi Wu, Zhen Jin, Liang-Jun Yan

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The Role of Sirt3 in Kidney Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Total flavonoids ofIranian journal of basic medical sciences · 2024
    Article
  14. Review
  15. Article
  16. Pathomechanisms of Diabetic Kidney Disease.Journal of clinical medicine · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jinzi WuDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
Zhen JinDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, United States. Electronic address: liang-jun.yan@unthsc.edu.
University of North Texas Health Science Center · USUniversity of North Texas System · US

Funding

Dietary targeting of dihydrolipoamide dehydrogenase for stroke toleranceR01NS079792 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI FORSTER, MICHAEL J., YAN, LIANG-JUN · 2013 to 2017
$1.3M
NINDS NIH HHS R01 NS079792
6 · The paper itself

Abstract

Although the lung is one of the least studied organs in diabetes, increasing evidence indicates that it is an inevitable target of diabetic complications. Nevertheless, the underlying biochemical mechanisms of lung injury in diabetes remain largely unexplored. Given that redox imbalance, oxidative stress, and mitochondrial dysfunction have been implicated in diabetic tissue injury, we set out to investigate mechanisms of lung injury in diabetes. The objective of this study was to evaluate NADH/NAD

Indexed as

AnimalsDiabetes MellitusDihydrolipoamide DehydrogenaseElectron Transport Complex IGlucosephosphate DehydrogenaseGlutathioneHumansLungMitochondriaNADNADPNAD(P)H Dehydrogenase (Quinone)Oxidation-ReductionOxidative StressPoly(ADP-ribose) PolymerasesRatsDihydrolipoamide DehydrogenaseElectron Transport Complex IGlucosephosphate DehydrogenaseGlutathioneNADNADPNAD(P)H Dehydrogenase (Quinone)NQO1 protein, ratPoly(ADP-ribose) PolymerasesSIRT3 protein, ratSirtuinsDiabetesLung injuryMitochondrial abnormalitiesOxidative stressRedox imbalance

Identifiers

PMID27888691
PMCPMC5124358
OpenAlexW2555985376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.