Evidence map›Paper›PMID 27888602›Full record

ArticleStem cells (Dayton, Ohio)2017

A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells.

Gisela Pachón-Peña, Conor Donnelly, Catalina Ruiz-Cañada, Adam Katz, Sonia Fernández-Veledo, Joan Vendrell, Robert Sackstein

Open access · bronzeAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Encoding Cell-Surface Receptor Function Through Glycosylation: Lessons From CD44.Chembiochem : a European journal of chemical biology · 2026
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  16. [The effects of CD44 fucosylation on fluid adhesion force of rabbit bone marrow mesenchymal stem cells].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Gisela Pachón-PeñaDepartment of Dermatology, and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Conor DonnellyDepartment of Dermatology, and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Catalina Ruiz-CañadaDepartment of Dermatology, and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Adam KatzDepartment of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Sonia Fernández-VeledoHospital Universitario de Tarragona Joan XXIII. Institut d'Investigació Sanitària Pere Virgili Universitat Rovira i Virgili, Tarragona, Spain.
Joan VendrellHospital Universitario de Tarragona Joan XXIII. Institut d'Investigació Sanitària Pere Virgili Universitat Rovira i Virgili, Tarragona, Spain.
Robert SacksteinDepartment of Dermatology, and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USHarvard University · USCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESFlorida College · USInstituto de Salud Carlos III · ES

Funding

REGULATION OF LACTOSAMINYL GLYCAN BIOSYNTHESIS IN HEMATOPOIETIC CELLSP01HL107146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SACKSTEIN, ROBERT · 2011 to 2017
$17.7M
NHLBI NIH HHS P01 HL107146
6 · The paper itself

Abstract

The clinical effectiveness of systemically administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM-hMSCs) natively lack endothelial binding capacity, but express a CD44 glycovariant containing N-linked sialyllactosamines that can be α(1,3)-fucosylated using fucosyltransferase-VI (FTVI) to enforce sLe

Indexed as

Adipose TissueBone Marrow CellsCell AdhesionCell DifferentiationCell LineE-SelectinFibronectinsGene Expression RegulationGlycoproteinsGlycosylationGlycosyltransferasesHumansHyaluronan ReceptorsImmunophenotypingLigandsL-SelectinCD44 protein, humanE-SelectinFibronectinsGlycoproteinsGlycosyltransferasesHyaluronan ReceptorsLigandsL-SelectinNeuraminidasePolysaccharidesE-selectin ligandExofucosylationFucosyltransferaseGlycosyltransferase-programmed stereosubstitutionHematopoietic cell E-/L-selectin ligandMesenchymal stem cellSialyl Lewis XsLeX

Identifiers

PMID27888602
PMCPMC5367967
OpenAlexW2557362819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.