Evidence map›Paper›PMID 27888565›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Applying Mass Cytometry to the Analysis of Lymphoid Populations in Transplantation.

S M Krams, S Schaffert, A H Lau, O M Martinez

Open access · hybridAbstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Single cell immune profiling in transplantation research.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S M KramsDivision of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA.
S SchaffertInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA.
A H LauDivision of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA.
O M MartinezDivision of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Stanford University · US

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Biomarkers for Post-Transplant Lymphoproliferative Disorders in ChildrenU01AI104342 · NIAID · STANFORD UNIVERSITY · PI ESQUIVEL, CARLOS O · 2013 to 2018
$7.7M
TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
NK Cell Interactions in TransplantationR01AI044095 · NIAID · STANFORD UNIVERSITY · PI KRAMS, SHERI M. · 1999 to 2009
$2.6M
New Therapeutics for Post-Transplant Lymphoproliferative DisorderR01AI113130 · NIAID · STANFORD UNIVERSITY · PI MARTINEZ, OLIVIA M · 2016 to 2020
$2.0M
Plasmacytoid Dendritic Cell microRNAS in TransplantationR21AI119686 · NIAID · STANFORD UNIVERSITY · PI KRAMS, SHERI M. · 2016 to 2017
$440k
Targeting B Cell MicroRNA in Post-Transplant EBV-Associated B Cell LymphomaR21AI115313 · NIAID · STANFORD UNIVERSITY · PI MARTINEZ, OLIVIA M · 2016 to 2017
$435k
Functional Roles of NKp46 in TransplantationR21AI104230 · NIAID · STANFORD UNIVERSITY · PI KRAMS, SHERI M. · 2013 to 2014
$419k
Plasmacytoid Dendritic Cells and Their Role in Transplant ToleranceF32DK094548 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAU, AUDREY H · 2011 to 2014
$179k
NIAID NIH HHS R01 AI044095NIAID NIH HHS R01 AI113130NIAID NIH HHS R21 AI104230NIAID NIH HHS R21 AI115313NIAID NIH HHS R21 AI119686NIAID NIH HHS U01 AI104342NIDDK NIH HHS F32 DK094548NIDDK NIH HHS T32 DK007762NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

Single-cell flow cytometric techniques have been indispensable to improving our understanding of the phenotype and function of immune cell subsets that are important in both rejection and tolerance after transplant. Mass cytometry, or cytometry by time of flight, is a single-cell-based platform that utilizes antibodies conjugated to rare heavy metal ions for analysis of cellular proteins by a time-of-flight mass spectrometer. This new technology allows for the evaluation of >40 simultaneous cellular parameters in a single sample because the limitation of spectral overlap, seen in conventional flow cytometry, is eliminated. In this review, we discuss the current state of mass cytometry, describe the advantages and disadvantages compared with multiparameter flow cytometry, introduce novel methods of high-dimensional data analysis and visualization, and review some recent studies using mass cytometry to profile the immune systems of healthy people and transplant recipients.

Indexed as

Organ TransplantationAnimalsFlow CytometryHumansImage Processing, Computer-AssistedLymphoid Tissuebasic (laboratory) research/sciencecellular biologyflow cytometryimmunobiologyinformaticslymphocyte biologymonitoring: immunetranslational research/science

Identifiers

PMID27888565
PMCPMC5526773
OpenAlexW2553245195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.