SynthesisEpilepsia2017
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy.
Synthesis in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06265103 (Epilepsy Learning Healthcare System), which is not on this map. Cited by 130 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epilepsy Learning Healthcare System (ELHS) for Quality Care & Outcome Improvement
Who cites it
130 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Elevated suicide risk in individuals with epilepsy: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Causal relationship between gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: A bidirectional Mendelian randomization study.Brain and behavior · 2023Pooled it
- A systematic review of the epidemiology of epilepsy in Mexico during 1970 to 2020.Arquivos de neuro-psiquiatria · 2023Pooled it
- Drug-resistant epilepsy and mortality-Why and when do neuromodulation and epilepsy surgery reduce overall mortality.Epilepsia · 2022Pooled it
- Pre-Existing Medical Conditions: A Systematic Literature Review of a Silent Contributor to Adult Drowning.International journal of environmental research and public health · 2022Pooled it
- Premature Mortality, Risk Factors, and Causes of Death Following Childhood-Onset Neurological Impairments: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.Systematic reviews · 2020Pooled it
- Pooled it
- One-year follow-up of a remotely delivered epilepsy self-management program in high-risk people with epilepsy.Epilepsy & behavior : E&B · 2019Trial
- Residential greenness, air pollution, and epilepsy: Insight in genetic susceptibility and life expectancy.Journal of advanced research · 2026Article
- Lived experiences of young people with epilepsy in a resource-constraint setting: Contemporary findings from Cape Coast, Ghana.Epilepsy & behavior reports · 2026Article
- Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic-clonic seizures.Epilepsia open · 2026Article
- Silymarin Reverses Seizure-Precipitating Effects of Alcohol and Associated Psychiatric Comorbidities, and Neurotoxicity in Pentylenetetrazol Pre-Kindled Mice.Neurotoxicity research · 2026Article
- Does having bad epilepsy make you a good surgical candidate? A number needed to treat analysis.Epilepsia open · 2026Review
- Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States.Epilepsia open · 2026Article
- Prediction of Stimulation-Defined Eloquent Cortex Using Graph-Theoretical Connectivity from Electrocorticography During Presurgical Mapping.bioRxiv : the preprint server for biology · 2026Article
- The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy.Journal of neurochemistry · 2026Review
- Cenobamate's effect on mood and seizure frequency.Epilepsy & behavior : E&B · 2026Article
- Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat.Journal of neurochemistry · 2026Article
- Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE.Epilepsia open · 2026Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.