ArticleBiological trace element research2017
The Influence of the Dietary Cu-Glycine Complex on the Histomorphology of Cancellous Bone, Articular Cartilage, and Growth Plate as well as Bone Mechanical and Geometric Parameters Is Dose Dependent.
Article in Biological trace element research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Effects of dietary vitamin D supplementation on bone microarchitecture, mineralization, and mechanical properties in Wistar rat animal model.Scientific reports · 2026Article
- Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.Medicine · 2025Article
- Article
- Effects of dietary supplementation of organic and inorganic zinc on the performance characteristics, tissue mineralization, apparent mineral retention, and antioxidant status of broiler chicks.BMC veterinary research · 2025Article
- Strategic incorporation of metal ions in bone regenerative scaffolds: multifunctional platforms for advancing osteogenesis.Regenerative biomaterials · 2025Review
- Promoting Angiogenesis/Osteogenesis by a New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro and In Vivo Investigation.Journal of biomedical materials research. Part A · 2025Article
- Polydopamine-Modified Polycaprolactone Scaffolds Loading Metal Nanoparticles for Bone Tissue Engineering.ACS omega · 2024Review
- The Effect of Doping on the Electrical and Dielectric Properties of Hydroxyapatite for Medical Applications: From Powders to Thin Films.Materials (Basel, Switzerland) · 2024Review
- Crosslinking strategies for biomimetic hydrogels in bone tissue engineering.Biophysical reviews · 2023Review
- Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1.Bioactive materials · 2023Article
- Broiler responses to copper levels and sources: growth, tissue mineral content, antioxidant status and mRNA expression of genes involved in lipid and protein metabolism.BMC veterinary research · 2022Article
- Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering.Bioactive materials · 2022Review
- The Impact of Zn, Cu and Fe Chelates on the Fatty-Acid Profile and Dietary Value of Broiler-Chicken Thigh Meat.Animals : an open access journal from MDPI · 2021Article
- Copper-based biomaterials for bone and cartilage tissue engineering.Journal of orthopaedic translation · 2021Review
- Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Mineral Nutritional Status of Yaks (Animals : an open access journal from MDPI · 2019Article
- The Influence of the Partial Replacing of Inorganic Salts of Calcium, Zinc, Iron, and Copper with Amino Acid Complexes on Bone Development in Male Pheasants from Aviary Breeding.Animals : an open access journal from MDPI · 2019Article
- Effect of Dietary Phytase Supplementation on Bone and Hyaline Cartilage Development of Broilers Fed with Organically Complexed Copper in a Cu-Deficient Diet.Biological trace element research · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper (Cu) is required for all basic biochemical and physiological processes. The objective of this study was to compare the effect of two different chemical forms (sulfates and glycinate chelates also below the recommended dose) of Cu administered to adult rats on the biomechanical and morphometric properties of femur. Male rats at the age of 12 weeks were used in the 12-week experiment. The control diet provided the required Cu level from sulfate (S-Cu), and the other diets were supplemented with Cu-glycine complex. The Cu-Gly-treatment, irrespective of its concentration, did not influence the bone mass and length. The Cu-Gly-treatment in 100 and 75% of daily demand increased mechanical endurance. The Cu-Gly-treatment (regardless of its concentration) increased the real bone volume in epiphysis and decreased the total thickness and zone I of the articular cartilage compared to the control group supplemented with S-Cu. The Cu-Gly-treatment enhanced the content of proteoglycans (except the OG50 group). Dietary Cu given to adult rats in the Cu-Gly complex covering the daily demand in 75% exerted a positive effect on bone metabolism and appeared to be the most effective among the investigated doses of the organic form.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.