Evidence map›Paper›PMID 27888284›Full record

ArticlePsychopharmacology2017

Attenuation of the anxiogenic effects of cocaine by 5-HT

Adam K Klein, Michael A Brito, Sayeh Akhavan, Dylan R Flanagan, Nikki Le, Tatum Ohana, Anand S Patil, Erin M Purvis, Carl Provenzano, Alex Wei and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Activation of 5-HTBehavioural brain research · 2019
    Article
  5. The 5-HTPsychopharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Adam K KleinBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Michael A BritoBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Sayeh AkhavanBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Dylan R FlanaganBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Nikki LeBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Tatum OhanaBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Anand S PatilBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Erin M PurvisBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Carl ProvenzanoBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Alex WeiBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Lucy ZhouBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA.
Aaron EttenbergBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, 93106-9660, USA. Aaron.ettenberg@psych.ucsb.edu.
University of California, Santa Barbara · USBehavioral Pharma (United States) · US

Funding

Opponent process properties of cocaineR01DA033370 · NIDA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ETTENBERG, AARON · 2013 to 2017
$1.6M
NIDA NIH HHS R01 DA033370
6 · The paper itself

Abstract

rationaleCocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states.

objectivesThe present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration.

methodsMale Sprague-Dawley rats were fitted with bilateral infusion cannula aimed at the BNST and then trained to traverse a straight alley once a day for a single 1 mg/kg i.v. cocaine infusion delivered upon goal-box entry on each of 16 consecutive days/trials. Intracranial infusions of CP 94,253 (0, 0.25, 0.5, or 1.0 μg/side) were administered to inhibit local 5-HT release via activation of 5-HT

resultsIntra-BNST infusions of the 5-HT

conclusionsInhibition of 5-HT

Indexed as

AnxietyAnimalsAutoreceptorsBenzopyransCocaineDopamine Uptake InhibitorsDrug-Seeking BehaviorLocomotionMaleMorpholinesMotivationPyridinesRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1BSelf Administration2-(((3-(morpholinylmethyl)-2H-chromen-8-yl)oxy)methyl)morpholineAutoreceptorsBenzopyransCocaineCP 94253Dopamine Uptake InhibitorsMorpholinesPyridinesReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor Antagonists5-HTAnxietyCocaineDrug abuseDrug aversionDrug rewardExtended amygdalaOperant runwaySelf-administrationSerotonin

Identifiers

PMID27888284
PMCPMC5226880
OpenAlexW2550626834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.