Evidence map›Paper›PMID 27888197›Full record

ArticleThe Journal of endocrinology2017

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine.

Xiaochuan Chen, Amy C Kelly, Dustin T Yates, Antoni R Macko, Ronald M Lynch, Sean W Limesand

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

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  14. Chronically elevated norepinephrine concentrations lower glucose uptake in fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  15. Article
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  17. Postnatal Nutrient Repartitioning due to Adaptive Developmental Programming.The Veterinary clinics of North America. Food animal practice · 2019
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Xiaochuan ChenChongqing Key Laboratory of Forage & HerbivoreCollege of Animal Science and Technology, Southwest University, Chongqing, China.
Amy C KellySchool of Animal and Comparative Biomedical SciencesUniversity of Arizona, Tucson, Arizona, USA.
Dustin T YatesSchool of Animal and Comparative Biomedical SciencesUniversity of Arizona, Tucson, Arizona, USA.
Antoni R MackoSchool of Animal and Comparative Biomedical SciencesUniversity of Arizona, Tucson, Arizona, USA.
Ronald M LynchDepartment of PhysiologyUniversity of Arizona, Tucson, Arizona, USA.
Sean W LimesandSchool of Animal and Comparative Biomedical SciencesUniversity of Arizona, Tucson, Arizona, USA limesand@email.arizona.edu.
University of Arizona · US

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Prevention of Placental Insufficiency Improves Beta-Cells FunctionR01DK084842 · NIDDK · UNIVERSITY OF ARIZONA · PI SEAN W LIMESAND · 2009 to 2026
$5.6M
NHLBI NIH HHS T32 HL007249NIDDK NIH HHS R01 DK084842
6 · The paper itself

Abstract

Complications in pregnancy elevate fetal norepinephrine (NE) concentrations. Previous studies in NE-infused sheep fetuses revealed that sustained exposure to high NE resulted in lower expression of α

Indexed as

Adaptation, PhysiologicalAnimalsFemaleGlucoseInsulinIslets of LangerhansNorepinephrinePregnancyPrenatal Exposure Delayed EffectsSheepGlucoseInsulinNorepinephrineadrenergic receptorcatecholaminefetal stressislets of Langerhansβ-cell

Identifiers

PMID27888197
PMCPMC5173394
OpenAlexW2552384734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.