Trial reportJournal of vascular and interventional radiology : JVIR2017
Percutaneous Image-Guided Cryoablation for the Treatment of Phantom Limb Pain in Amputees: A Pilot Study.
Trial report in Journal of vascular and interventional radiology : JVIR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Beyond traditional therapies: a network meta-analysis on the treatment efficacy for chronic phantom limb pain.Regional anesthesia and pain medicine · 2025Pooled it
- Cryoneurolysis for phantom limb pain: a systematic review.Pain management · 2024Pooled it
- Ultrasound-guided Percutaneous Cryoneurolysis to Treat Chronic Postamputation Phantom Limb Pain: A Multicenter Randomized Controlled Trial.Anesthesiology · 2023Trial
- Treatment of residual and phantom limb pain using percutaneous ablation: a systematic review and meta-analysis.Frontiers in rehabilitation sciences · 2026Review
- Cryoneurolysis as a Neuroregenerative Intervention for Chronic Painful Mononeuropathies: A Four-Patient Case Series and Discussion.Cardiovascular and interventional radiology · 2025Article
- Intraoperative cryo nerve block during lower extremity amputation prevents the development of phantom limb pain.Journal of vascular surgery cases and innovative techniques · 2025Article
- Benign Soft Tissue Lesions Responsible for Pain: When and How Should the IR Intervene.Cardiovascular and interventional radiology · 2025Review
- Innovations in Chronic Pain Treatment: A Narrative Review on the Role of Cryoneurolysis.Medicina (Kaunas, Lithuania) · 2025Review
- Common Cryoneurolysis Targets in Pain Management: Indications, Critical Anatomy, and Potential Complications.Seminars in interventional radiology · 2025Review
- Applications of Cryoneurolysis in Chronic Pain Management: a Review of the Current Literature.Current pain and headache reports · 2024Review
- Introduction to interventional radiology's role in palliative care for children with cancer: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper.Pediatric blood & cancer · 2023Article
- An open-label, single-arm trial of cryoneurolysis for improvements in pain, activities of daily living and quality of life in patients with symptomatic ankle osteoarthritis.Osteoarthritis and cartilage open · 2022Article
- Treating phantom limb pain: cryoablation of the posterior tibial nerve.Radiology case reports · 2022Article
- Efficacy of cryoneurolysis in the management of chronic non-cancer pain: A systematic review and meta-analysis.Indian journal of anaesthesia · 2022Article
- Icing the Pain-Ultrasound-Guided Cryoablation of Symptomatic Post-Amputation Stump Neuroma.Cardiovascular and interventional radiology · 2022Observational
- Auricular Therapy for Treating Phantom Limb Pain Accompanied by Jumping Residual Limb: A Short Review and Case Study.Pain and therapy · 2021Article
- Cryoanalgesia of the anterior femoral cutaneous nerve (AFCN) for the treatment of neuropathy-mediated anterior thigh pain: anatomy and technical description.Skeletal radiology · 2021Article
- Interventional Cryoneurolysis: What Is the Same, What Is Different, What Is New?Seminars in interventional radiology · 2019Review
- Principles of designing a clinical trial: optimizing chances of trial success.Current behavioral neuroscience reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo prospectively evaluate percutaneous image-guided nerve cryoablation for treatment of refractory phantom limb pain (PLP) in a pilot cohort for purposes of deriving parameters to design a larger, randomized, parallel-armed, controlled trial. MATERIALS AND
methodsFrom January 2015 to January 2016, 21 patients with refractory PLP underwent image-guided percutaneous cryoneurolysis procedures. Visual analog scale scores were documented at baseline and 7, 45, and 180 days after the procedure. Responses to a modified Roland Morris Disability Questionnaire were documented at baseline and 7 and 45 days after the procedure.
resultsTechnical success rate of the procedures was 100%. There were 6 (29%) minor procedure-related complications. Disability scores decreased from a baseline mean of 11.3 to 3.3 at 45-day follow-up (95% confidence interval 5.8, 10.3; P < .0001). Pain intensity scores decreased from a baseline mean of 6.2 to 2.0 at long-term follow-up (95% confidence interval 2.8, 5.6; P < .0001).
conclusionsImage-guided percutaneous nerve cryoablation is feasible and safe and may represent a new efficacious therapeutic option for patients with phantom pains related to limb loss.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.