Evidence map›Paper›PMID 27887893›Full record

ArticleParkinsonism & related disorders2017

Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures.

Jacob A Lafo, Ania Mikos, Paul C Mangal, Bonnie M Scott, Erin Trifilio, Michael S Okun, Dawn Bowers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Clinical correlates of abnormal subcortical volumes in Essential Tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jacob A LafoDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA. Electronic address: jlafo@phhp.ufl.edu.
Ania MikosDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Institute for Regenerative Medicine, University of Zurich, Center for Prevention and Dementia Therapy, Wagistrasse 14, 8952 Schileren, Switzerland. Electronic address: mikos.ania@gmail.com.
Paul C MangalDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA. Electronic address: pmangal@phhp.ufl.edu.
Bonnie M ScottDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA. Electronic address: bonnie.m.scott@phhp.ufl.edu.
Erin TrifilioDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA. Electronic address: etrif07@phhp.ufl.edu.
Michael S OkunDepartment of Neurology, University of Florida College of Medicine, University of Florida, HSC Box 100236, Gainesville, FL 32610-0236, USA. Electronic address: okun@neurology.ufl.edu.
Dawn BowersDepartment of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Department of Neurology, University of Florida College of Medicine, University of Florida, HSC Box 100236, Gainesville, FL 32610-0236, USA. Electronic address: dawnbowers@phhp.ufl.edu.
University of Florida Health · USUniversity of Florida · USUniversity of Zurich · CH

Funding

Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential TremorUH3NS095553 · NINDS · UNIVERSITY OF FLORIDA · PI FOOTE, KELLY D, GUNDUZ, AYSEGUL · 2016 to 2023
$2.1M
Dissociating Components of Anhedonia: Pilot Behavioral and fMRI Data for the Effort Expenditure for Rewards TaskR03MH109336 · NIMH · UNIVERSITY OF FLORIDA · PI BOWERS, DAWN · 2015 to 2016
$150k
NIMH NIH HHS R03 MH109336NINDS NIH HHS T32 NS082168NINDS NIH HHS UH3 NS095553
6 · The paper itself

Abstract

backgroundEssential tremor is a highly prevalent movement disorder characterized by kinetic tremor and mild cognitive-executive changes. These features are commonly attributed to abnormal cerebellar changes, resulting in disruption of cerebellar-thalamo-cortical networks. Less attention has been paid to alterations in basic emotion processing in essential tremor, despite known cerebellar-limbic interconnectivity.

objectivesIn the current study, we tested the hypothesis that a psychophysiologic index of emotional reactivity, the emotion modulated startle reflex, would be muted in individuals with essential tremor relative to controls.

methodsParticipants included 19 essential tremor patients and 18 controls, who viewed standard sets of unpleasant, pleasant, and neutral pictures for six seconds each. During picture viewing, white noise bursts were binaurally presented to elicit startle eyeblinks measured over the orbicularis oculi.

resultsConsistent with past literature, controls' startle eyeblink responses were modulated according to picture valence (unpleasant > neutral > pleasant). In essential tremor participants, startle eyeblinks were not modulated by emotion. This modulation failure was not due to medication effects, nor was it due to abnormal appraisal of emotional picture content.

conclusionsNeuroanatomically, it remains unclear whether diminished startle modulation in essential tremor is secondary to aberrant cerebellar input to the amygdala, which is involved in priming the startle response in emotional contexts, or due to more direct disruption between the cerebellum and brainstem startle circuitry. If the former is correct, these findings may be the first to reveal dysregulation of emotional networks in essential tremor.

Indexed as

AgedAged, 80 and overAnalysis of VarianceAttentionBlinkingElectromyographyEmotionsEssential TremorEvoked Potentials, MotorFemaleHumansMaleMiddle AgedPhotic StimulationReflex, StartleAmygdalaCerebellumEmotionEssential tremorStartle

Identifiers

PMID27887893
PMCPMC7953172
OpenAlexW2555573339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.