ArticleMalaria journal2016
The hide and seek of Plasmodium vivax in West Africa: report from a large-scale study in Beninese asymptomatic subjects.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Prevalence and risk of Plasmodium vivax infection among Duffy-negative individuals: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Epidemiological insights and genetic diversity of the Duffy binding protein of Plasmodium vivax in Duffy-negative Cameroonians.PLoS neglected tropical diseases · 2026Article
- Genomic analysis of Plasmodium vivax field isolates circulating in sub-Saharan Africa.Communications biology · 2025Article
- Circulation of non-falciparum malaria species in West Africa: A literature review from 2000 to 2024.MalariaWorld journal · 2025Review
- Circulation of Non-Open forum infectious diseases · 2024Article
- Presence of Plasmodium vivax in Anopheles gambiae and absence in other malaria vectors in Cove-Zagnanando-Ouinhi health zone in southern Benin, West Africa.Malaria journal · 2024Article
- Molecular speciation of Plasmodium and multiplicity of P. falciparum infection in the Central region of Ghana.PLOS global public health · 2024Article
- Potential hidden Plasmodium vivax malaria reservoirs from low parasitemia Duffy-negative Ethiopians: Molecular evidence.PLoS neglected tropical diseases · 2023Article
- Using Serological Markers for the Surveillance ofPathogens (Basel, Switzerland) · 2023Article
- Evidence of Transmission ofInsects · 2023Article
- Prevalence and distribution of Plasmodium vivax Duffy Binding Protein gene duplications in Sudan.PloS one · 2023Article
- The Black Box of Cellular and Molecular Events ofInternational journal of molecular sciences · 2022Review
- The global burden of Plasmodium vivax malaria is obscure and insidious.PLoS medicine · 2021Article
- Zoonotic Malaria: Non-Pathogens (Basel, Switzerland) · 2021Review
- The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo.Nature communications · 2021Article
- Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Epidemiological and entomological studies of malaria transmission in Tibati, Adamawa region of Cameroon 6 years following the introduction of long-lasting insecticide nets.Parasites & vectors · 2021Article
- Comparison of capillary and venous blood for malaria detection using two PCR-based assays in febrile patients in Sierra Leone.Malaria journal · 2021Article
- High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana.Malaria journal · 2021Article
- Basic Research ofFrontiers in cellular and infection microbiology · 2021Review
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasmodium vivax is considered to be absent from western Africa, where the prevalence of Duffy-negative red blood cell phenotype proves to be high. Several studies have, however, detected P. vivax infection cases in this part of Africa, raising the question of what is the actual prevalence of P. vivax in local populations.
methodsThe presence of P. vivax was investigated in a large population of healthy blood donors in Benin using microscopy, serology and molecular detection. The seroprevalence was measured with species-specific ELISA using two recombinant P. vivax proteins, namely rPvMSP1 and rPvCSP1. Specific molecular diagnosis of P. vivax infection was carried out using nested-PCR. The performances and cut-off values of both rPvCSP1 and rPvMSP1 ELISA were first assessed using sera from P. vivax-infected patients and from non-exposed subjects.
resultsAmong 1234 Beninese blood donors, no parasites were detected when using microscopy, whereas 28.7% (354/1234) of patients exhibited had antibodies against rPvMSP1, 21.6% (266/1234) against rPvCSP1, and 15.2% (187/1234) against both. Eighty-four samples were selected for nested-PCR analyses, of which 13 were positive for P. vivax nested-PCR and all Duffy negative.
conclusionThe results of the present study highlight an unexpectedly high exposure of Beninese subjects to P. vivax, resulting in sub-microscopic infections. This suggests a probably underestimated and insidious parasite presence in western Africa. While the vaccination campaigns and therapeutic efforts are all focused on Plasmodium falciparum, it is also essential to consider the epidemiological impact of P. vivax.
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