ArticleBMC infectious diseases2016
Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02382822 (Copenhagen Comorbidity in HIV Infection Study), which is not on this map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Copenhagen Comorbidity in HIV Infection Study
Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- De novo electrocardiographic abnormalities in persons living with HIV.Scientific reports · 2021Trial
- Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies.Aging cell · 2026Article
- Systematic screening for age-related comorbidities: Health care optimization among persons with HIV in an outpatient setting.HIV medicine · 2026Article
- Inter-arm Blood Pressure Difference is Associated With Both Coronary Artery Disease and Peripheral Artery Disease in People With HIV.Open forum infectious diseases · 2026Article
- Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Incidence of Confirmed Influenza and Pneumococcal Infections and Vaccine Uptake Among Virologically Suppressed People Living with HIV.Vaccines · 2025Article
- Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort Study.Biomolecules · 2025Article
- Cytomegalovirus Antibodies and Coronary Artery Disease in People with HIV: A Cohort Study.Viruses · 2025Article
- Microbiome profiling reveals gut bacterial species associated with rapid lung function decline in people with HIV.Frontiers in immunology · 2025Article
- Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV.The Journal of infectious diseases · 2024Article
- Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.Frontiers in medicine · 2024Article
- Coronary Artery Disease in Persons With Human Immunodeficiency Virus Without Detectable Viral Replication.Open forum infectious diseases · 2023Article
- Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark.Vaccines · 2023Article
- Article
- Aortic aneurysms and markers of platelet activation, hemostasis, and endothelial disruption in people living with HIV.Frontiers in immunology · 2023Article
- The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV.Journal of obesity · 2023Article
- Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency.BMC infectious diseases · 2022Article
- Monocyte count and soluble markers of monocyte activation in people living with HIV and uninfected controls.BMC infectious diseases · 2022Article
- Article
- Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication.Scientific reports · 2021Observational
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis. The study primarily targets cardiovascular, respiratory, and hepatic non-AIDS comorbidity. METHODS/
designThe Copenhagen comorbidity in HIV-infection (COCOMO) study is an observational, longitudinal cohort study. The study was initiated in 2015 and recruitment is ongoing with the aim of including 1500 PLWHIV from the Copenhagen area. Follow-up examinations after 2 and 10 years are planned. Uninfected controls are derived from the Copenhagen General Population Study (CGPS), a cohort study including 100,000 uninfected participants from the same geographical region. Physiological and biological measures including blood pressure, ankle-brachial index, electrocardiogram, spirometry, exhaled nitric oxide, transient elastography of the liver, computed tomography (CT) angiography of the heart, unenhanced CT of the chest and upper abdomen, and a number of routine biochemical analysis are uniformly collected in participants from the COCOMO study and the CGPS. Plasma, serum, buffy coat, peripheral blood mononuclear cells (PBMC), urine, and stool samples are collected in a biobank for future studies. Data will be updated through periodical linking to national databases. DISCUSSION: As life expectancy for PLWHIV improves, it is essential to study long-term impact of HIV and cART. We anticipate that findings from this cohort study will increase knowledge on non-AIDS comorbidity in PLWHIV and identify targets for future interventional trials. Recognizing the demographic, clinical and pathophysiological characteristics of comorbidity in PLWHIV may help inform development of new guidelines and enable us to move forward to a more personalized HIV care.
trial registrationClinicalTrials.gov: NCT02382822 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.