Evidence map›Paper›PMID 27886569›Full record

ArticleJournal of affective disorders2017

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients.

W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Trial
  2. Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

W Vaughn McCallAugusta University/Medical College of Georgia, Georgia, USA. Electronic address: wmccall@augusta.edu.
Sarah H LisanbyNational Institute of Mental Health, Bethesda, Maryland, USA.
Peter B RosenquistAugusta University/Medical College of Georgia, Georgia, USA.
Mary DooleyMedical University of South Carolina, Charleston, USA.
Mustafa M HusainUniversity of Texas Southwestern Medical Center, Dallas, USA.
Rebecca G KnappMedical University of South Carolina, Charleston, USA.
Georgios PetridesZucker Hillside Hospital/North Shore-LIJ Health System, New York, USA.
Matthew V RudorferNational Institute of Mental Health, Bethesda, Maryland, USA.
Robert C YoungNew York Presbyterian/Weill Cornell Medical Center, New York, USA.
Shawn M McClintockUniversity of Texas Southwestern Medical Center, Dallas, USA.
Martina MuellerMedical University of South Carolina, Charleston, USA.
Joan PrudicNew York Presbyterian/Weill Cornell Medical Center, New York, USA; Columbia University and New York State Psychiatric Institute, New York, USA.
Robert M GreenbergNYU School of Medicine, New York, USA.
Richard D WeinerDuke University School of Medicine, Durham, USA.
Samuel H BailineZucker Hillside Hospital/North Shore-LIJ Health System, New York, USA.
Mary Anne RileyAugusta University/Medical College of Georgia, Georgia, USA.
Laryssa McCloudAugusta University/Medical College of Georgia, Georgia, USA.
Charles H KellnerIcahn School of Medicine at Mount Sinai, New York, USA.
CORE/PRIDE Work Group
Augusta University · USMedical University of South Carolina · USNational Institute of Mental Health · USThe University of Texas Southwestern Medical Center · USCornell University · USDuke University · USIcahn School of Medicine at Mount Sinai · USNew York State Psychiatric InstituteNew York University · USNorthwell Health · USZucker Hillside Hospital · US

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
2/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH084241 · NIMH · DUKE UNIVERSITY · PI WEINER, RICHARD D. · 2009 to 2013
$2.1M
1/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH055495 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLNER, CHARLES H · 2009 to 2013
$2.0M
3/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH081362 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KNAPP, REBECCA GRANT · 2009 to 2013
$1.8M
4/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086123 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PETRIDES, GEORGIOS · 2009 to 2013
$1.5M
7/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086127 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCALL, WILLIAM VAUGHN · 2009 to 2013
$1.1M
8/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086122 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2009 to 2013
$1.0M
5/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086130 · NIMH · MAYO CLINIC ROCHESTER · PI SAMPSON, SHIRLENE MARIE · 2009 to 2011
$610k
NIMH NIH HHS U01 MH055495NIMH NIH HHS U01 MH081362NIMH NIH HHS U01 MH084241NIMH NIH HHS U01 MH086122NIMH NIH HHS U01 MH086123NIMH NIH HHS U01 MH086127NIMH NIH HHS U01 MH086130
6 · The paper itself

Abstract

introductionPatients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT.

methodsHRQOL data from 240 depressed patients over the age of 60 was measured with the Medical Outcomes Study Short Form 36 (SF-36). The SF-36 was measured before and after a course of acute ECT. Predictors of change in HRQOL scores were identified by generalized linear modeling.

resultsAt baseline, participants showed very poor HRQOL. After treatment with ECT, the full sample showed marked and significant improvement across all SF-36 measures, with the largest gains seen in dimensions of mental health. Across all participants, the Physical Component Summary (PCS) score improved by 2.1 standardized points (95% CI, 0.61,3.56), while the Mental Component Summary (MCS) score improved by 12.5 points (95% CI, 7.2,10.8) Compared with non-remitters, remitters showed a trend toward greater improvement in the PCS summary score of 2.7 points (95%CI, -0.45, 5.9), while the improvement in the MCS summary score was significantly greater (8.5 points, 95% CI, 4.6,12.3) in the remitters than non-remitters. Post-ECT SF-36 measurements were consistently and positively related to baseline scores and remitter/non-remitter status or change in depression severity from baseline. Objective measures of cognitive function had no significant relationships to changes in SF-36 scores. LIMITATIONS: This study's limitations include that it was an open label study with no comparison group, and generalizability is limited to elderly patients. DISCUSSION: ECT providers and elderly patients with MDD treated with ECT can be confident that ECT will result in improved HRQOL in the short-term. Attaining remission is a key factor in the improvement of HRQOL. Acute changes in select cognitive functions were outweighed by improvement in depressive symptoms in determining the short term HRQOL of the participants treated with ECT.

Indexed as

Quality of LifeAgedAged, 80 and overCognitionDepressive DisorderElectroconvulsive TherapyFemaleHealth StatusHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesRemission InductionTreatment OutcomeECTElderlyMajor depressive disorderQuality of life

Identifiers

PMID27886569
PMCPMC5278419
OpenAlexW2552663465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.