Evidence map›Paper›PMID 27886408›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2017

Role of ROCK2 in CD4

D I Kasahara, J A Mathews, F M C Ninin, A P Wurmbrand, J K Liao, S A Shore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

D I KasaharaMolecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J A MathewsMolecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
F M C NininMolecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
A P WurmbrandMolecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J K LiaoDepartment of Medicine, University of Chicago, Chicago, IL, USA.
S A ShoreMolecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
University of Chicago · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
LIPOPROTEINS EFFECTS ON G PROTEIN FUNCTIONR01HL052233 · NHLBI · UNIVERSITY OF CHICAGO · PI LIAO, JAMES KUANG-JAN · 1995 to 2016
$5.3M
Impact of Obesity on Airway Responses to Air PollutionR01ES013307 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SHORE, STEPHANIE A · 2005 to 2019
$5.2M
Translational Research in Lung Biology and DiseaseP30GM103532 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2012 to 2016
$3.7M
Novel Signaling Pathways in Ischemic StrokeR01NS070001 · NINDS · UNIVERSITY OF CHICAGO · PI LIAO, JAMES KUANG-JAN · 2010 to 2014
$1.8M
Mechanisms Underlying Vascular AgingR01HL136962 · NHLBI · UNIVERSITY OF CHICAGO · PI LIAO, JAMES KUANG-JAN · 2018 to 2021
$1.8M
Rho Kinase and Airway HyperresponsivenessR01HL091933 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHORE, STEPHANIE A · 2010 to 2013
$1.6M
Resolution of ozone induced lung injury requires gamma/delta T cellsF32ES022556 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI MATHEWS, JOEL A · 2013 to 2015
$139k
NHLBI NIH HHS R01 HL052233NHLBI NIH HHS R01 HL091933NHLBI NIH HHS R01 HL136962NHLBI NIH HHS T32 HL007118NIEHS NIH HHS F32 ES022556NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES013307NIGMS NIH HHS P30 GM103532NINDS NIH HHS R01 NS070001
6 · The paper itself

Abstract

backgroundRho kinases (ROCKs) contribute to allergic airways disease. ROCKs also play a role in lymphocyte proliferation and migration.

objectiveTo determine the role of ROCK2 acting within CD4

methodsROCK2-haploinsufficient (ROCK2

resultsOVA-induced increases in bronchoalveolar lavage lymphocytes, eosinophils, IL-13, IL-5, and eotaxin were reduced in ROCK2

conclusionROCK2 contributes to allergic airways responses likely via effects within ASM cells and within non-lymphocyte cells involved in lymphocyte activation and migration into the airways.

Indexed as

Adoptive TransferAnimalsBronchoalveolar Lavage FluidCD4-Positive T-LymphocytesDisease Models, AnimalGene DeletionGoblet CellsHypersensitivityMaleMiceMice, KnockoutOvalbuminRespiratory Mucosarho-Associated KinasesT-Cell Antigen Receptor SpecificityOvalbuminrho-Associated KinasesRock2 protein, mouseanimal modelsasthmabasic mechanismslymphocytesT cells

Identifiers

PMID27886408
PMCPMC5280456
OpenAlexW2554403675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.