Trial reportActa paediatrica (Oslo, Norway : 1992)2017
Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity.
Trial report in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2023Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Association between antenatal corticosteroid use and perinatal mortality among preterm births in hospitals in Tanzania.PloS one · 2021Trial
- Effects of Sample Deposition Medium and Drying on Spectroscopic Quantification of Lipid Biomarkers in Respiratory Distress Syndrome.Biosensors · 2026Article
- Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- A Rapid and Simplified Approach to Correct Atmospheric Absorptions in Infrared Spectra.Analytical chemistry · 2024Article
- The use of antenatal corticosteroids in preterm labour for the prevention of perinatal mortality in hospitals in Tanzania.African health sciences · 2024Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Artificial Intelligence in NICU and PICU: A Need for Ecological Validity, Accountability, and Human Factors.Healthcare (Basel, Switzerland) · 2022Article
- Prediction of Neonatal Respiratory Distress Biomarker Concentration by Application of Machine Learning to Mid-Infrared Spectra.Sensors (Basel, Switzerland) · 2022Article
- Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates.Biomedical journal · 2021Review
- How to improve CPAP failure prediction in preterm infants with RDS: a pilot study.European journal of pediatrics · 2021Observational
- Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates: 2. Clinical part.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimRespiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation.
methodsConcentrations of the most surface-active lung phospholipid dipalmitoylphosphatidylcholine and sphingomyelin in gastric aspirates from premature infants were measured by mass spectrometry and expressed as the lecithin/sphingomyelin ratio (L/S). The same aspirates were analysed with mid-infrared spectroscopy. Subsequently, L/S was measured in gastric aspirates and oropharyngeal secretions from another group of premature infants using spectroscopy and the results were compared with RDS development. The 10-minute analysis required 10 μL of aspirate.
resultsAn L/S algorithm was developed based on 89 aspirates. Subsequently, gastric aspirates were sampled in 136 infants of 24-31 weeks of gestation and 61 (45%) developed RDS. The cut-off value of L/S was 2.2, sensitivity was 92%, and specificity was 73%. In 59 cases, the oropharyngeal secretions had less valid L/S than gastric aspirate results.
conclusionOur rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted RDS with high sensitivity.
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