ArticleBritish journal of pharmacology2017
Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia.Journal of cellular and molecular medicine · 2021Article
- Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.Cells · 2020Article
- Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.Biomolecules · 2019Review
- Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression.Cardiovascular research · 2019Article
- Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes.British journal of pharmacology · 2018Article
- AnFrontiers in pharmacology · 2018Article
- Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells.British journal of pharmacology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeClemizole, a histamine H EXPERIMENTAL APPROACH: Whole-cell patch techniques was used to examine the effects of clemizole on hERG channel current, I KEY
resultsClemizole decreased hERG current by blocking both open and closed states of the channel in a concentration-dependent manner (IC CONCLUSION AND IMPLICATIONS: Our results provide the first evidence that clemizole potently blocks hERG channels, moderately inhibits cardiac I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.