ArticleHistochemistry1989
Calcitonin gene-related peptide (CGRP) immunoreactivity in the neuroendocrine Merkel cells and nerve fibres of pig and human skin.
Article in Histochemistry, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- Choline acetyltransferase as a marker for Merkel cells in mucosal and skin tissues.Journal of oral biosciences · 2026Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis.Development (Cambridge, England) · 2015Article
- Merkel cells and neurons keep in touch.Trends in cell biology · 2015Review
- Neurotransmitters and synaptic components in the Merkel cell-neurite complex, a gentle-touch receptor.Annals of the New York Academy of Sciences · 2013Review
- Calcitonin gene-related peptide inhibits chemokine production by human dermal microvascular endothelial cells.Brain, behavior, and immunity · 2011Article
- Merkel cells, a new localization of prepro-orexin and orexin receptors.Journal of anatomy · 2004Article
- Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs.The Journal of physiology · 2002Article
- The relationship between cutaneous C fibre type and antidromic vasodilatation in the rabbit and the rat.The Journal of physiology · 1997Article
- Neural cell adhesion molecule immunoreactivity in Merkel cells and Merkel cell tumours.Virchows Archiv : an international journal of pathology · 1995Article
- Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods.The Histochemical journal · 1994Review
- Production and characterization of a monoclonal antibody against human calcitonin gene-related peptide (CGRP) and its immunohistochemical application to salivary glands.The Histochemical journal · 1994Article
- Immunohistochemical studies of neurochemical markers in normal human buccal mucosa.Histochemistry · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of calcitonin gene-related peptide (CGRP) in the skin of pig snout and human fingertip was investigated using immunohistochemical techniques. CGRP immunoreactivity was found in Merkel cells and nerve fibres of both species. In pig snout skin, Merkel cells containing CGRP were seen forming clusters at the tips of rete ridge epidermis and in the external root sheath of sinus hair follicles (vibrissae). Human Merkel cells immunostained for CGRP were found isolated or forming small groups in the basal layer of glandular epidermal ridges. In all cases, immunoreactivity was more intense on the side of the Merkel cell facing the associated nerve terminal (which was never positive for CGRP). This part of the Merkel cell has the greatest density of dense-cored granules, suggesting that CGRP must be stored in these granules. Nerve bundles containing CGRP-immunoreactive fibres were found at dermal and hypodermal level, and blood vessels were often surrounded by CGRP nerve fibres. In pig snout skin some nerve fibres containing CGRP penetrated the epidermis and terminated as free endings, and in the human fingertip a small number of CGRP-immunoreactive nerve fibres were seen in Meissner's corpuscles.
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Registered trials
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