Evidence map›Paper›PMID 27886311›Full record

ArticleOrganic & biomolecular chemistry2016

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.

R Dondi, E Yaghini, K M Tewari, L Wang, F Giuntini, M Loizidou, A J MacRobert, I M Eggleston

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy.Journal of enzyme inhibition and medicinal chemistry · 2020
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Multicomponent peptide assemblies.Chemical Society reviews · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

R DondiDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
E YaghiniUCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
K M TewariDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.ORCID http://orcid.org/0000-0001-7384-7112
L WangDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk and School of Pharmaceutical Sciences, Shandong University, Jinan, China.
F GiuntiniDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
M LoizidouUCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
A J MacRobertUCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
I M EgglestonDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BBD0113291Biotechnology and Biological Sciences Research Council BB/D012783/1Biotechnology and Biological Sciences Research Council BBD0127831
6 · The paper itself

Abstract

Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

Indexed as

Drug Delivery SystemsLightPhotochemotherapyAntimicrobial Cationic PeptidesMolecular StructurePhenothiazinesPorphyrinsAntimicrobial Cationic PeptidesPhenothiazinesPorphyrins

Identifiers

PMID27886311
PMCPMC5166568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.