ArticleScientific reports2016
Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Modulatory effect of opioid administration on the activity of cholinesterase enzyme: a systematic review of mice/rat models.Environmental science and pollution research international · 2021Pooled it
- Synchronous activation of striatal cholinergic interneurons induces local serotonin release.Nature communications · 2026Article
- Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.bioRxiv : the preprint server for biology · 2025Article
- Crosstalk Between Glycinergic and N-Methyl-D-Aspartate Receptor-Mediated Glutamatergic Transmission in Behaviours Associated with Opioid Use Disorder.International journal of molecular sciences · 2025Review
- Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.eLife · 2024Article
- Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.bioRxiv : the preprint server for biology · 2024Article
- Control of dopamine communication by opioids: glutamate enters the discussion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor.Nature communications · 2023Article
- Article
- Opioid withdrawal: role in addiction and neural mechanisms.Psychopharmacology · 2023Review
- Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor.MedComm · 2022Review
- Nicotine and opioid co-dependence: Findings from bench research to clinical trials.Neuroscience and biobehavioral reviews · 2022Review
- Prenatal opioid exposure reprograms the behavioural response to future alcohol reward.Addiction biology · 2022Article
- Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum.Biomedicines · 2022Article
- Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.Frontiers in molecular neuroscience · 2022Review
- Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons.eLife · 2021Article
- Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments.Neuron · 2021Article
- Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In addition to dopamine neuron firing, cholinergic interneurons (ChIs) regulate dopamine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals. Synchronous activity of ChIs is necessary to evoke dopamine release through this pathway. The frequency-dependence of disynaptic nicotinic modulation has led to the hypothesis that nAChRs act as a high-pass filter in the dopaminergic microcircuit. Here, we used optogenetics to selectively stimulate either ChIs or dopamine terminals directly in the striatum. To measure the functional consequence of dopamine release, D2-receptor synaptic activity was assessed via virally overexpressed potassium channels (GIRK2) in medium spiny neurons (MSNs). We found that nicotinic-mediated dopamine release was blunted at higher frequencies because nAChRs exhibit prolonged desensitization after a single pulse of synchronous ChI activity. However, when dopamine neurons alone were stimulated, nAChRs had no effect at any frequency. We further assessed how opioid receptors modulate these two mechanisms of release. Bath application of the κ opioid receptor agonist U69593 decreased D2-receptor activation through both pathways, whereas the μ opioid receptor agonist DAMGO decreased D2-receptor activity only as a result of cholinergic-mediated dopamine release. Thus the release of dopamine can be independently modulated when driven by either dopamine neurons or cholinergic interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.